All doctoral dissertations are checked for plagiarism before they are submitted to the doctorate committee.

Can animal venoms yield novel antimicrobial peptides?

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

We study the physics of a broad range of biological and soft materials

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

Promotor: M.A.G.J. Orrit

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

The mechanism of the electrochemical reduction of dioxygen by a mononuclear pyridylalkylamine copper complex was investigated (see picture). It was shown that in neutral aqueous solution dioxygen undergoes stepwise reduction, wherein hydrogen peroxide plays a key role. The rate constants determined…

And its application in deciphering hominin diets in palaeolithic eurasia

Promotor: V. Vitelli, Co-promotor: J. Paulose

Our cantilevers have a low intrinsic damping rate: this enables us to measure with low noise, since damping is proportionate to noise. However, when the magnet is close to the surface of a sample we want to study, we measure a much higher effective damping rate. This is caused by magnetic interaction…

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

In the contemporary myriad of definitions and approaches of landscape, the starting points and limits of the concept of landscape biography are being explored, but also tested in this thesis. What exactly is a landscape biography? What does it constitute of? Is landscape biography just a narration of…

High resolution altitude data created by airborne LiDAR allow the investigation of large areas and often inaccessible tracts of land and has the potential to reveal undiscovered archaeological heritage.

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Promotor: T.H. Oosterkamp

Promotor: W. Jiskoot, Co-promotor: A. Hawe

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

This volume edited by Jan Lucassen and Leo Lucassen aims to quantify and qualify cross-cultural global migrations and was published in the series 'Studies in Global Migration History'.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.

Promotor: Prof.dr. D. Bouwmeester, Co-promotor: M.P. van Exter

Prehistoric burial mounds are still ubiquitous in the Northwest European landscape, but not much is known on the landscape they were part of, nor on what preceded them.

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

This article provides an in‐depth assessment of lone actor terrorists’ attack planning and preparation.

Sarah Giest and Annemarie Samuels, both Assistant Professors at Leiden University, researched the quality and coverage of the data being collected for policiymakers to be used, specifically pertaining to minority groups.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Promotor: M. de Jong, Co-Promotor: Samtleben

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

The Faculty of Humanities

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…

With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

This research note argues that the “lone wolf” typology should be fundamentally reconsidered.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.