102 search results for “enzymatic teamwork” in the Public website
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities
Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…
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Do fungi differ? Understanding the mechanisms of mycorrhizal fungal impacts on soil C sequestration
How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?
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Chenguang Gao
Science
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Riccardo Mancinelli
Science
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Ben Kuipers
Faculty Governance and Global Affairs
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Using soil inoculations for ecological restorations
How soil microbial composition impacts structure and composition of the aboveground plant and animal communities?
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Paradigm-shifting theory highlights the importance of substrate flexibility in enzymatic reactions
Leiden chemists have proposed a new model for enzymatic reactions, in which the flexibility of the substrate is much more important than previously thought. Their results are paradigm-shifting and could have major implications for drug research and enzyme engineering. Publication in Angewandte Chemi…
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Teamwork psychologists and educators appreciated and rewarded by KNAW
A team of developmental psychologists and educators are involving young people in the communication about brain development. A second team of Leiden neuroscientists conducts research into music and spatial skills and searches for healthcare applications. Both teams were awarded a sum of 10,000 euros…
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Total Synthesis of Alginate and Zwitterionic Sp1 Oligosaccharides
The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.
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Enzymatic reduction of oxygen by small laccase
PhD Defence
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Protein Facility
The Protein Centre can supply you with purified proteins that are essential for many experiments, ranging from in vitro inhibitor screening and enzymatic analysis to manipulation of life cells.
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Deciphering the complex paramagnetic NMR spectra of small laccase
Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Comenius Senior Fellow grants for three Leiden lecturers
Three lecturers from Leiden University have been awarded a 100,000-euro Comenius Teaching Fellowship within the scope of the Senior Fellows programme. The grant will enable them and their project teams to carry out their own teaching innovation project.
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On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases
Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive.
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Scalable organic solvent free supercritical fluid spray drying process for producing dry protein formulations
In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.
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Applications of Natural Deep Eutectic Solvents to Extraction and Preservation of Biomolecules
The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.
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Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle and Lars Jeuken.
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T-CYCLE EPR: Development at 275 GHz for the study of reaction kinetics & intermediates
A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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About the programme
The minor consists of three courses in each period, and a group project running the whole semester. The first period starts off with the three-week course Anthropocene: The Planet of Man, which serves as an introduction into the subject as well as for building a community of students. This course is…
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Evolutionary Developmental Biology of Bitterling Fish
We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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Prof. B.M. Telders
The aim of the competition is to prolong the legacy of Professor Benjamin Marius Telders, who became a professor of international law at Leiden University in 1937.
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PROTEOMINING: a novel proteomics-based pipeline for drug and enzyme discovery in filamentous actinomycetes
Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?
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Minor Sustainable Chemistry and Biotechnology
If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…
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Programme structure
Throughout your 3-year Security Studies programme you explore the effects of events (such as war or natural disaster), understand them via relevant academic perspectives, and actively design strategies and solutions to resulting security challenges.
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Dissemination
This section features online articles by or about the team members of the Food Citizens? project. .
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African percussion (djembé)
Arts and leisure, Arts and leisure
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About Us
Telders Competition
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Werken bij het ISSC
Werken bij een topuniversiteit? Met uitstekende carrièremogelijkheden? Ontdek de mogelijkheden bij de Universiteit Leiden.
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Our People
The Leiden Leadership Centre is an interdisciplinary network organisation branching out from its place within the Institute of Public Administration, Faculty of Governance and Global Affairs (Leiden University in The Hague). The LLC functions as a platform by connecting students, practitioners, and…
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Marcellus Ubbink receives grant for research into evolution of enzymes
The Dutch organisation for scientific research NWO has announced that it will award an ENW-Klein grant to Marcellus Ubbink (LIC) for his research into the role of temperature in the evolution of enzymes. Sixteen grants have been awarded in total.
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Why Leiden University?
The ICT in the Public Sector master’s aims to provide a deeper understanding of the issues, challenges and opportunities of ICT-management and -alignment in a governmental environment.
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Why Leiden University?
The ICT in Business master’s programme aims to provide a deeper understanding of the issues, challenges and opportunities of this subject. The programme focuses on management and alignment of ICT in a business context.
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Career preparation
Leiden University offers several services to help you prepare for the jobmarket. But where you end up depends on the chosen study direction, your own skills and interests.
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Why Leiden University?
The ICT in Business and the Public Sector master’s programme aims to provide a deeper understanding of the issues, challenges and opportunities of this subject. The programme focuses on management and alignment of ICT in a business and socio-technical context.
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Towards a working model of industry and higher education collaboration in enhancing engineers’ soft skills for better employability
The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.
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What we have done, how, and why
The Food citizens? team has included two post-docs, three Ph.D. candidates and two research assistants working with the Principal Investigator. The Winter School involved nine Masters and Ph.D. candidates from the universities of Bologna, Gothenburg, Kaunas, Leiden, Louvain, Tromsø, Turin and Utrech…
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After graduation
The European Law Master’s programme offered by the Europa Institute at Leiden University will provide you with the skills necessary for a successful legal career in the private or public sector.
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Research
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Rob Verpoorte receives prestigious pharmocognosy award
The American Society of Pharmacognosy (ASP) has given the Varro E. Tyler prize to Rob Verpoorte, for his outstanding lifetime contributions to the science of nature as source of medicine.
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The Dakhleh Oasis Project
Update : March 2020 A.J. Mills
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Junior Technician for Metabolic Engineering
Science, Institute of Biology Leiden (IBL)
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Tutor for the Bachelor Security Studies
Governance and Global Affairs, Institute of Security and Global Affairs
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About the programme
As a student in Security Studies you are a socially engaged critical thinker eager to study real-life security cases in an academic setting. You focus not just on the broad context of these issues but also on the role of government, institutions and media.
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3 years junior teacher in Computer Science (Docent 4, 0.6-0.8 fte)
Science, Leiden Institute of Advanced Computer Science (LIACS)
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Statistics & Data Science (MSc)
The master’s programme Statistics & Data Science provides students with a thorough introduction to the general philosophy and methodology of statistical modelling and data analysis. The programme has two specialisations: Data Science and Statistical Science.