Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

How soil microbial composition impacts structure and composition of the aboveground plant and animal communities?

Leiden chemists have proposed a new model for enzymatic reactions, in which the flexibility of the substrate is much more important than previously thought. Their results are paradigm-shifting and could have major implications for drug research and enzyme engineering. Publication in Angewandte Chemi…

A team of developmental psychologists and educators are involving young people in the communication about brain development. A second team of Leiden neuroscientists conducts research into music and spatial skills and searches for healthcare applications. Both teams were awarded a sum of 10,000 euros…

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

PhD Defence

The Protein Centre can supply you with purified proteins that are essential for many experiments, ranging from in vitro inhibitor screening and enzymatic analysis to manipulation of life cells.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Three lecturers from Leiden University have been awarded a 100,000-euro Comenius Teaching Fellowship within the scope of the Senior Fellows programme. The grant will enable them and their project teams to carry out their own teaching innovation project.

Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive.

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle and Lars Jeuken.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

The minor consists of three courses in each period, and a group project running the whole semester. The first period starts off with the three-week course Anthropocene: The Planet of Man, which serves as an introduction into the subject as well as for building a community of students. This course is…

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

The aim of the competition is to prolong the legacy of Professor Benjamin Marius Telders, who became a professor of international law at Leiden University in 1937.

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…

Throughout your 3-year Security Studies programme you explore the effects of events (such as war or natural disaster), understand them via relevant academic perspectives, and actively design strategies and solutions to resulting security challenges.

This section features online articles by or about the team members of the Food Citizens? project. .

Arts and leisure, Arts and leisure

Telders Competition

Werken bij een topuniversiteit? Met uitstekende carrièremogelijkheden? Ontdek de mogelijkheden bij de Universiteit Leiden.

The Leiden Leadership Centre is an interdisciplinary network organisation branching out from its place within the Institute of Public Administration, Faculty of Governance and Global Affairs (Leiden University in The Hague). The LLC functions as a platform by connecting students, practitioners, and…

The Dutch organisation for scientific research NWO has announced that it will award an ENW-Klein grant to Marcellus Ubbink (LIC) for his research into the role of temperature in the evolution of enzymes. Sixteen grants have been awarded in total.

The ICT in the Public Sector master’s aims to provide a deeper understanding of the issues, challenges and opportunities of ICT-management and -alignment in a governmental environment.

The ICT in Business master’s programme aims to provide a deeper understanding of the issues, challenges and opportunities of this subject. The programme focuses on management and alignment of ICT in a business context.

Leiden University offers several services to help you prepare for the jobmarket. But where you end up depends on the chosen study direction, your own skills and interests.

The ICT in Business and the Public Sector master’s programme aims to provide a deeper understanding of the issues, challenges and opportunities of this subject. The programme focuses on management and alignment of ICT in a business and socio-technical context.

The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.

The Food citizens? team has included two post-docs, three Ph.D. candidates and two research assistants working with the Principal Investigator. The Winter School involved nine Masters and Ph.D. candidates from the universities of Bologna, Gothenburg, Kaunas, Leiden, Louvain, Tromsø, Turin and Utrech…

The European Law Master’s programme offered by the Europa Institute at Leiden University will provide you with the skills necessary for a successful legal career in the private or public sector.

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

The American Society of Pharmacognosy (ASP) has given the Varro E. Tyler prize to Rob Verpoorte, for his outstanding lifetime contributions to the science of nature as source of medicine.

Update : March 2020 A.J. Mills

Science, Institute of Biology Leiden (IBL)

Governance and Global Affairs, Institute of Security and Global Affairs

As a student in Security Studies you are a socially engaged critical thinker eager to study real-life security cases in an academic setting. You focus not just on the broad context of these issues but also on the role of government, institutions and media.

Science, Leiden Institute of Advanced Computer Science (LIACS)

The master’s programme Statistics & Data Science provides students with a thorough introduction to the general philosophy and methodology of statistical modelling and data analysis. The programme has two specialisations: Data Science and Statistical Science.