Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

How soil microbial composition impacts structure and composition of the aboveground plant and animal communities?

Leiden chemists have proposed a new model for enzymatic reactions, in which the flexibility of the substrate is much more important than previously thought. Their results are paradigm-shifting and could have major implications for drug research and enzyme engineering. Publication in Angewandte Chemi…

A team of developmental psychologists and educators are involving young people in the communication about brain development. A second team of Leiden neuroscientists conducts research into music and spatial skills and searches for healthcare applications. Both teams were awarded a sum of 10,000 euros…

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

PhD Defence

The Protein Centre can supply you with purified proteins that are essential for many experiments, ranging from in vitro inhibitor screening and enzymatic analysis to manipulation of life cells.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive.

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

The aims of research and teaching within the Educational Sciences programme are to understand in how individuals develop and learn and to optimize education for all individuals.

Learning and Behaviour Problems researches how learning disabilities are developed and what the possible interventions are. The programme group studies common learning problems such as dyslexia, hyperlexia and dyscalculia, as well as learning disabilities caused by AHDH, ADD or speech and language d…

Cognitive psychology is the study of cognitive functions such as attention, memory, consciousness, emotion, language and action control. The goal is to understand the complex relationships between brain, mind and behavior.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

The aim of the competition is to prolong the legacy of Professor Benjamin Marius Telders, who became a professor of international law at Leiden University in 1937.

The program group Forensic Family and Youth Care Studies of the Institute of Education and Child Studies deals with the developmental processes of vulnerable children, young people and families. We try with our research to find out how problematic development processes can be prevented and how we can…

The unit Health, Medical and Neuropsychology offers eduction and conducts research on related fields of Health, Medical and Neuropsychology.

The Leiden Institute for Brain and Cognition (LIBC) is a network focusing on science valorisation and outreach, stimulating interdisciplinary exchange of knowledge and expertise on topics related to brain and cognition.

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

Throughout your 3-year Security Studies programme you explore the effects of events (such as war or natural disaster), understand them via relevant academic perspectives, and actively design strategies and solutions to resulting security challenges.

Arts and leisure, Arts and leisure

The Leiden Leadership Centre is an interdisciplinary network organization branching out from its place within the Institute of Public Administration, Faculty of Governance and Global Affairs (Leiden University in The Hague). The LLC functions as a platform by connecting students, practitioners, and…

If government wants to solve societal challenges and improve society, individual public organizations must be able to achieve results. In the Public Management and Leadership specialisation, you learn how management and leadership shape the performance of organizations in the public sector. In times…

Telders Competition

The Faculty of Social and Behavioural Sciences brings together high-quality research and outstanding teaching.

The Dutch organisation for scientific research NWO has announced that it will award an ENW-Klein grant to Marcellus Ubbink (LIC) for his research into the role of temperature in the evolution of enzymes. Sixteen grants have been awarded in total.

Leiden University offers several services to help you prepare for the jobmarket. But where you end up depends on the chosen study direction, your own skills and interests.

The ICT in the Public Sector master’s aims to provide a deeper understanding of the issues, challenges and opportunities of ICT-management and -alignment in a governmental environment.

The ICT in Business master’s programme aims to provide a deeper understanding of the issues, challenges and opportunities of this subject. The programme focuses on management and alignment of ICT in a business context.

The European Law Master’s programme offered by the Europa Institute at Leiden University will provide you with the skills necessary for a successful legal career in the private or public sector.

The ICT in Business and the Public Sector master’s programme aims to provide a deeper understanding of the issues, challenges and opportunities of this subject. The programme focuses on management and alignment of ICT in a business and socio-technical context.

The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.

If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

In 2020, many of our staff and students have again won prestigious prizes and been awarded important research subsidies.

Update : March 2020 A.J. Mills

As a student in Security Studies you are a socially engaged critical thinker eager to study real-life security cases in an academic setting. You focus not just on the broad context of these issues but also on the role of government, institutions and media.

- How to deconvolute metabolic mixture of precursors and products by biontransformation? - How to optimize the reaction conditions to produce bioactive compounds in biotransformation? - What is the effect of co-treating fungi or bacteria for biotransformations?

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. The University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP) work…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

A European consortium has provided a disruptive technological breakthrough to allow the discovery and characterization of novel enzymes for industrial biotechnology. The technology will open the way to more efficient industrial processes such as in the biofuel, animal feed and paper and pulp industr…

Create a world of opportunities with a master's degree from Leiden University.