Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

D1.2 reports on the findings of an analysis of framework conditions relevant in the context of the data economy from a legal, a socio-economic and a technological perspective. The analysis is a key foundation for the creation of an initial, heuristic model of the European data economy. The deliverable…

Using the principles of Industrial Ecology in Environmental Policy making in two cases: transition to a hydrogen economy and chlorinated compounds.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

Thanks to data science, we can chart and search enormous quantities of related information. This generates all kinds of new insights, for example in complex global financial structures or such societal problems as loneliness.

Supervisor: Gerard van Westen

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

The Western Mediterranean is a key region to understand human dispersal events within and out of the African continent as well as for the eventual replacement of Neanderthals by anatomically modern humans during the Pleistocene. Central to any conclusive interpretation of archaeological and palaeoclimatic…

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

Promotor: S.M. Verduyn Lunel

Novel methods for understanding key aspects that are essential to the future of Bayesian inference for high- or infinite-dimensional models and data.

In 2016, CML published over 90 papers, successfully crowdfunded the Living Lab project, celebrated a royal honour for associate professor Hans de Iongh and contributed to the Global Soil Biodiversity Atlas. CML awarded five PhDs and taught students from all over the world how to contribute to sustainability.…

In 2017, In 2017 we published over 70 papers, appointed two new professors, researched microplastic contamination in European beach sediment and modelled future energy demand. We awarded six PhDs and taught students from all over the world how to contribute to sustainability. We wish you a pleasant…

In 2015, CML published over 70 papers, contributed to the United Nations conference on climate change in Paris, won awards and advised the Dutch government on the safe use of pesticides. CML awarded 11 PhDs and taught students from all over the world how to contribute to sustainability. We wish you…

Political institution (like the Council of the European Union and the European Parliament) generate large bodies of text. These great amounts of text can impossibly be read by a researcher. Contrary to human researchers, computers are able to read thousands of documents a day. In this research project…

PhD Defence

In 2013-2014, CML published over 100 papers, contributed to various international sustainability debates, renovated our building and educated thousands of students from all over the world through our MOOC. These accomplishments and many more are highlighted in this booklet, CML wish you a pleasant…

Eco-innovations like more economical cars do not generate the environmental benefits predicted by the manufacturers. This is the result of the so-called rebound effect, concludes Leiden industrial ecologist David Font Vivanco on the basis of new algorithms. PhD defence 3 March.

What workflow of non-destructive techniques provides accurate, valuable data to improve our understanding of Caribbean archaeological landscapes? How were Amerindian settlements configured?

Supervisor: P.J.J. Hooykaas

This project aims at describing the Khoisan languages !Ora (Korana/Griqua) and !Ui of South Africa.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

Understanding the water use of power production is an important step to both a sustainable energy transition and an improved understanding of water conservation measures. However, there are large differences across the literature that currently present barriers to decision making.

PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.

The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.

Analysis of drug adversity

In the CarbonCap project, consumption oriented technological options and policy measures are identified as an addition to the present EU and world climate policy.

The world abounds with different footprints that calculate human impact on the environment. Environmental specialist Kai Fang is the first person to have developed a family of footprints that allow better measurement of environmental damage and the depletion of natural sources. PhD defence on 24 Nov…

This thesis focuses on addressing four research problems in designing embedded streaming systems.

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The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.

Description of Triple bottom line approach for risk-benefit analysis of genetically modified crops.

What are the flows of C&DW (e.g. bricks, concrete, gypsum and wood) in the case study countries ? How to define the specification for each material to be quantified? What indicators should be used to identify the pattern of each C&DW management system? How to interpret the MFA results in relation…

How can we best deal with the current problems caused by the human impact on the nitrogen cycle? How do we make the transition to a sustainable society? As of 1 September, nitrogen expert Jan Willem Erisman will be working on these questions at Leiden University: he will exchange the Louis Bolk Institute…

Co-ordination Action for Innovation in Life-Cycle Analysis for Sustainability: deepening, broadening and leaping forward the LCA methodology.

Fokelien Kootstra defended her thesis on 23 April 2019

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

What are the rights of migrants in Morocco and how does this receiving state and migrants deal with them in practice?

The current study focuses on Walpole’s social network and the language as contained in the letters of the network members.

International trade plays a critical role in global food security, with global consumption having highly localized environmental impacts.

Governance of Sustainability is a two-year programme, worth 120 European Credit Transfer System points (ECTS).

Lecture, Sociolinguistics Series

We study the link between the acoustic, behavioral and physiological health of birds and prominent pollution factors. We aim to explore causation through experimental studies on detrimental factors like traffic noise, particulate matter and chemical toxins. Our primary target is scientific progress…

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.