Promotores: J.N. Kok, H.J. Hoogeboom

Identification and characterization of components of DNA repair pathways and their role in Agrobacterium T-DNA integration and repair of CRISPR/Cas induced DSBs.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.

Promotor: R.D. Gill, F. Taroni

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Natural resources are becoming increasingly scarce. If we want to maintain our current standard of living, we will need inventive solutions. The researchers at the Institute of Environmental Sciences (CML) share their thoughts on how to achieve a fully circular economy in which as little use as possible…

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Various departments of the university have worked on developing the institution’s environmental policy plan: het Milieubeleidsplan Universiteit Leiden 2016-2020.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.

This research programme aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services to facilitate strategic management of natural resources. To this end, we address urgent challenges in relation to the mechanisms involved…

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Mission: The Environmental Biology department aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services. Through this understanding they facilitate strategic management of natural resources by addressing urgent challenges…

Lecture

In the absence of stringent and coordinated international action, States might seek alternatives to promote environmental protection unilaterally.

The project’s overall goal is to improve Indonesia’s environmental legal framework and its implementation by strengthening the regulatory capacity of the government, and by enhancing the capacity of CSOs and scholars to hold the government accountable for its regulatory performance.

Promotor: W.T. de Groot

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Evaluating the environmental consequences of diet changes in the European Union.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Science, Institute of Environmental Sciences (CML)

Leiden physicist Maarten Kruithof has discovered how our DNA is infallibly able to fold itself and to unfold again. In his dissertation he demonstrates how DNA is folded in a single long, very flexible spiral.

CML is an institute of the Faculty of Science of Leiden University.

This project aims to explore the environmental impact of early Roman expansion (4th/3rd century BC) through a program of dating and ecological sampling of traces of field systems (centuriations).

Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.

The state of our environment is a global concern. Despite an increasing awareness, setting internationally binding and ambitious commitments has proven to be a very difficult process. Can unilateral trade measures form an alternative and contribute to global environmental protection?

What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

They were called 'annoying brats', the group of campaigning scientists who in 1978 founded what is now an internationally acclaimed ecological research institute. Their stories and those of the current staff of the Institute of Environmental Sciences are described in the book 'Forty years of Leiden…

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

Social and Behavioural Sciences, Political Science

Theoretical physicist Helmut Schiessel receives an NWO Projectruimte grant of 390,000 euro. He will use this budget to hire a postdoc and a PhD student to continue his research on flexibility of double stranded DNA.

In an Advance Online Publication biophysicist John van Noort and others show using magnetic tweezers that DNA is folded in compliant helices of chromatin. This allows enzymes access to the DNA needed for gene expression. Van Noort's research group made the discovery in close partnership with researchers…

Researchers from Biomon have used DNA-techniques to find 40 different species of fish in the river Dommel. This technique is capable of detecting more species than conventional methods of measuring.

How can we quantify the density of species within a community through environmental DNA concentrations?

Schneider

A delegation of the Institute of Environmental Sciences (CML) of the Faculty of Science of Leiden University, led by the Dean of the Faculty of Science: Prof.dr. Geert de Snoo, visited the Kenyan ambassador Mr. Lawrence Lenayapa and his staff on Monday 29 of October in The Hague.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.