110 search results for “electrophoresis-mass spectrometry” in the Public website
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Probing a new volume regime in metabolomics with capillary electrophoresis-mass spectrometry
Ramautar
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Sheathless capillary electrophoresis-mass spectrometry as a new approach for analyzing the polar metabolome
Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.
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Capillary Electrophoresis-Mass Spectrometry for Metabolomics
In the field of metabolomics, capillary electrophoresis-mass spectrometry (CE-MS) has become a very useful analytical technique for the profiling of highly polar and charged metabolites in biological samples. In order to highlight the unique features of CE-MS for metabolomics studies, Dr. Rawi Ramautar…
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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Thomas HankemeierScience
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Enabling volume-restricted metabolomics using next-generation microscale analytical tools
Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.
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Key publications
Key publications of the Biomedical Microscale Analytics group.
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Technician Mass Spectrometry
Science, Institute of Biology Leiden (IBL)
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Quantification in untargeted mass spectrometry-based metabolomics
Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken
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Postdoc candidate in analytical chemistry / mass spectrometry / proteomics
Science, Leiden Institute of Chemistry (LIC)
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Interview with Rawi Ramautar at ASMS Conference 2015
Live from the ASMS Conference 2015 in Saint Louis: Baljit Ubhi, our Metabolomics Specialist, has a coffee with Rawi Ramautar, Assistant Professor at the Leiden Academic Center for Drug Research.
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers
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Polymers in the Liver: Metabolism and Regulation
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
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Rawi RamautarScience
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Hocelayne Paulino FernandesScience
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FERNANDA Santos ReginaldoScience
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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BioMedical Metabolomics Facility Leiden
The BioMedical Metabolomics Facility Leiden (BMFL) offers a highly structured environment for advanced metabolomics studies. BMFL builds on fully validated, state-of-the-art platforms that each cover a part of the human metabolism and together span the complete human metabolome.
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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken
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Sebastian PomplunScience
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New insights into Neandertal knowledge from the mass-spectrometry analysis of plastic containers
The analysis of protein residues extracted from the storage containers of circa 50,000 year old bone-tools reveals Neandertal strategic selection of bovid ribs to make some of their “lissoirs”.
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Vascular and Regenerative Medicine
Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
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Young Hae ChoiScience
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
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Glycosylation profiling with mass spectrometry
PhD Defence
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Mass spectrometry based protein profiling
PhD Defence
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Mass spectrometry based protein profiling
PhD Defence
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Clinical Glycomics of Antibodies by Mass Spectrometry
PhD Defence
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Collaborative and effective drug development
There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…
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Facilities
Our facilities cover:
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Boosting mass spectrometry-based analytics for biopharma
PhD Defence
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Statistical Methods for Mass Spectrometry-based Clinical Proteomics
PhD Defence
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David Overy
Dr. at Agriculture and AgriFood Canada, Ottawa Research & Development Center - Canada
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
PhD Defence
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Biomarker Discovery in High Grade Sarcomas by Mass Spectrometry Imaging
PhD Defence
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Data analysis for mass spectrometry imaging: methods and applications
PhD Defence
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Joachim Kopka
PhD at the Max Planck Institute of Molecular Plant Physiology, Golm – Germany
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Development of novel metabolomics and systems pharmacology methods
We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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and functional characterization of therapeutic glycoproteins by mass spectrometry
PhD Defence
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Lab-on-a-tissue: Optimization of On-Tissue Chemistry for Improved Mass Spectrometry Imaging
PhD Defence
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The Palaeoproteomic Identification of Pleistocene Hominin Skeletal Remains:
Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition