Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Promotores: K.J. Batenburg, B. Koren

Promotores: R. Tijdeman, K.J. Batenburg

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

Promotor: K.J. Batenburg

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Science, Institute of Biology Leiden (IBL)

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Science

How do we experience electronic music? How does electronic music operate on perceptual, cognitive and affective levels? What are the common concepts activated in the listener’s mind when listening to electronic music? Why and how are these concepts activated?

From The Cognitive Continuum of Electronic Music:

What is the Electronics Department?

Science

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

This thesis describes a study from both a theoreticaL and an experimental point of view.

PhD defence

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

The aim of this facility is to accelerate biomedical research by providing access to advanced light and electron microscopy and by sharing expertise about sample preparation, imaging modalities, data storage and image analysis.

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

The principal aim of this research is to explore the confrontation between voice and electronics. These are often seen as being radically different from one another and many characteristics seem to be in opposition between them. However, they also have characteristics in common and they can influence…

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

Promotor: Prof.dr. C.W.J. Beenakker

The dissertation describes TEM experiments on heterogeneous catalysts.

Chinese and Leiden scientists came together in Leiden to study the intricacies of modern visual techniques.

My research focusses on site-specific compositional and performance practices of music for organ and electronics and their musical-spatial values.

What is the effect of practicing with electronic books on reading skills for grade 1 students?

Beenakker

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Promotores: G.W. Canters, T.J. Aartsma

With tomography it is possible to reconstruct the interior of an object without destroying.

For the first time, physicists have visualized the ‘melting’ of electrons inside a special class of insulators. It allows electrons to move freely and turns the insulator into a metal and possibly later into a superconductor. Publication in Nature Physics.

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

During the Dutch Mathematical Congress, Joost Batenburg has been awarded the Philips Mathematics Prize for PhD students.

PNAS publication on protein encounter complexes

Physicist Daniël Geelen has developed a new microscope that uses low-energy electrons. Those are less harmful to biological and organic materials. Geelen defends his PhD thesis on May 31st.

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

The use of a new type of detector has generated a strong improvement in the resolution of electron microscopes. The 'low-energy electron microscope' (LEEM) can now be used for research on the thinnest possible materials. The tests with the detector represent the first result of the ESCHER project.