Bacteria are everywhere. They are the most abundant organisms on earth and impact all aspects of our lives. They determine our health and shape our environment. Ariane Briegel, professor of Ultrastructural Biology, freezes bacteria super fast to gain a true-to-nature image of the internal and external…

In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.

Conference

Electron microscopy has become an extremely important techniquein a wide variety of elds.

How do we experience electronic music? How does electronic music operate on perceptual, cognitive and affective levels? What are the common concepts activated in the listener’s mind when listening to electronic music? Why and how are these concepts activated?

From The Cognitive Continuum of Electronic Music:

What is the Electronics Department?

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

This thesis describes a study from both a theoreticaL and an experimental point of view.

The aim of this facility is to accelerate biomedical research by providing access to advanced light and electron microscopy and by sharing expertise about sample preparation, imaging modalities, data storage and image analysis.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Science

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

Ariane Briegel has been appointed Professor in the fìeld of Ultrastructural Biology within the Faculty of Science at the Institute of Biology from the 1st of December 2015. Her expertise is in using electron cryotomography to study how microbes sense and respond to their environment.

The principal aim of this research is to explore the confrontation between voice and electronics. These are often seen as being radically different from one another and many characteristics seem to be in opposition between them. However, they also have characteristics in common and they can influence…

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

How do bacteria sense and adapt to their environment? Ariane Briegel, Professor of Ultrastructural Biology, is intrigued by this question. Using new techniques, she produces three-dimensional images of bacteria that provide us with new clues about their sensory system.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

Promotor: Prof.dr. C.W.J. Beenakker

The dissertation describes TEM experiments on heterogeneous catalysts.

My research focusses on site-specific compositional and performance practices of music for organ and electronics and their musical-spatial values.

What is the effect of practicing with electronic books on reading skills for grade 1 students?

Beenakker

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Promotores: G.W. Canters, T.J. Aartsma

Freezing bacteria super fast to gain a true-to-nature image of the internal and external structure. Ariane Briegel Professor of Ultrastructural Biology came to Leiden specially to carry out this research. Leiden University is one of the few institutes in the world to have the necessary equipment. Inaugural…

For the first time, physicists have visualized the ‘melting’ of electrons inside a special class of insulators. It allows electrons to move freely and turns the insulator into a metal and possibly later into a superconductor. Publication in Nature Physics.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Physicist Daniël Geelen has developed a new microscope that uses low-energy electrons. Those are less harmful to biological and organic materials. Geelen defends his PhD thesis on May 31st.

PNAS publication on protein encounter complexes

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

The use of a new type of detector has generated a strong improvement in the resolution of electron microscopes. The 'low-energy electron microscope' (LEEM) can now be used for research on the thinnest possible materials. The tests with the detector represent the first result of the ESCHER project.

The Netherlands Organisation for Scientific Research (NWO) has made a subsidy of 17 million euros available to further develop a Netherlands network for electron microscopy (NEMI). The network comprises five UMCs and eight universities, with Utrecht in the coordinating role. From Leiden, the Institute…

Science Magazine has published three back-to-back papers on an important discovery in solid state physics. Leiden physicist Jan Zaanen wrote a Perspective article on the subject in the same issue of 4 March.

Leiden physicists found a surprising interaction between electrons and a resist layer. The resist appears to charge and discharge due to incoming electrons. Publication in Physical Review Letters.

Stem cells, Dr. Jekyll or Mr. Hyde? The Niko Tinbergen lecture 2019 was delivered by Hans Clevers. Before the main lecture, Ariane Briegel and Susana Chuva de Sousa Lopes told the audience about their fields of research in two shorter lectures.

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Chinese and Leiden scientists came together in Leiden to study the intricacies of modern visual techniques.

This dissertation derives from the development of tools for algorithmic composition which extract pitch materials from sound signals, analyzing them according to their timbral and harmonic properties, putting them into motion through diverse rhythmic and textural procedures.

Stacked layers of graphene can act like a mirror for beams of electrons. Physicists Daniël Geelen and colleagues discovered this using a new type of electron microscope. In an article in Physical Review Letters, they describe their results, which could lead to the development of optics for electron…

Optical detection of a single electron using a single molecule has never been done. Leiden physicist Michel Orrit and his team have now identified a molecule that is sensitive enough to detect an electron at a distance of hundreds of nanometers. The results are published as a cover article in ChemPh…

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

On February 2nd the book Beelden zonder weerga appears, written by professor in science history Dirk van Delft and biochemist Ton van Helvoort. They describe the rich history of electron microscopy, which comes to a conclusion in the final chapter with the current state-of-the-art ESCHER microscope…