We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

On 1 October 2019, Emile Cammeraat defended his thesis 'Economic Effects of Social Protection'. The doctoral research was supervised by Prof. K.P. Goudswaard and Prof. P.W.C. Koning.

Science, Leiden Institute of Chemistry (LIC)

Media in the Netherlands and abroad reported extensively about the drug research led by Leiden chemist Mario van der Stelt. In this research, Van der Stelt shows which unwanted side-effects a French drug candidate has.

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

More than half of Europeans speak two or more languages. Linguist Lisa Cheng investigates the various forms of multilingualism in Europe from a linguistic, cognitive and sociological perspective. She looks for instance at the way in which minority languages influence the standard language of a country,…

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

-

Supervisor: Lizi Xia

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

Promotor: R. Tijdeman

Development & Disease is one of the four research themes of the Institute of Biology Leiden.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Seven talented female scientists join the fight against cancer of the Oncode Insitute. Laura Heitman of the Leiden Academic Centre for Drug Research is one of the new Junior Investigators. ‘I hope to discover new druggable targets’.

Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…

It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…

How do different emotional expressions influence the behavior of other people in negotiations?

The Role and Effectiveness of the G20. In this article, published in The Changing Global Order part of the United Nations University Series on Regionalism book series, author Jaroslaw Kantorowicz discusses the evolution of the G20.

-

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

Artful Mathematics: The Heritage of M. C. Escher

Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.

In health care, artificial intelligence is quite normal: it is used, for example, as an aid in making diagnoses. However, artificial intelligence is not yet used as much in drug development. A new prestigious partnership is therefore going to investigate how artificial intelligence can contribute to…

Lecture

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

The Zmapp medicine has been developed with funding from the US government within the framework of the Small Business Innovation Research programme. The European Commission tried to emulate the success of this programme within the EU. Has its effort been adequate and sufficient? Is procurement of research…

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

What are interactive effects of human pressures on aquatic communities?

What is the best method and time to test the effectiveness of medicines? PhD student Rob van Wijk of the Leiden Academic Centre for Drug Research (LACDR) discovered zebrafish larvae are best used in drug research when they are five days old. His findings were published on 15 February in the journal…

Promotor: Prof.dr. A. Achucarro, Co-Promotor: J.W. van Holten

Currently, more than 80% of drugs are used in an off-label manner in critically ill neonates.

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.

What dose of medicine do you give a child? That depends to a large extent on how quickly their kidneys remove the drug from the blood. For ethical reasons it is impossible to measure this directly in little patients. PhD candidate Sinziana Cristea combined different types of modelling and lots of data…

Source: Mediators Inflamm (2014)

How can and should tasks and competences for the purpose of the criminal justice system (i.e. legislation, enforcement, the administration of justice and sentencing) be defined and formulated, while at the same time taking into account the chain concept, adjoining national and international legal domains…

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Description of Effects of glufosinate-ammonium on off crop vegetation.

Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…

-

Promotor: P.M. Brakefield

This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

How to improve the method in quantifying the combined effects of metal-based chemicals?