Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in…

Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Do selenium nanoparticles in fish food cause subtle alterations in behavior of fish: effect of particles size and concentration?

How to improve the method in quantifying the combined effects of metal-based chemicals?

Tools and Data of the department of Environmental Biology

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).

Mission: The Environmental Biology department aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services. Through this understanding they facilitate strategic management of natural resources by addressing urgent challenges…

A critical look at the impact assessment modelling of metals in Life Cycle Impact Assessment and improvement options.

In this project innovative technology for photovoltaics cells is developed and analysis of ecological and health related risks are explicitly accounted for.

PhD Defence

CML is an institute of the Faculty of Science of Leiden University.

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

The large-scale project NanoInformatics will assess the risks associated with nanoparticles. The project will be funded by the EU with 6.8 million euros and was launched at the beginning of this year. Three scientists from Leiden are involved. 'For the first time, this project combines the various experts…

Overview of all dissertations published by PhD candidates from CML.

Recent publications

Overview of the publications of the department of Industrial Ecology (1982-2015)

Overview of the publications of the department of Environmental Biology (1972-2015)