In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Unfolding potential

An assessment approach that tailors to children’s instructional needs

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

In this thesis, dynamic testing principles were applied to examine young children's potential for learning. Our studies focused on the role of cognitive flexibility, to further increase our understanding of the cognitive processes involved in children's ability to learn from instruction and feedback,…

The research of our group is centered around dynamical systems, functional analysis and their interplay.

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

Actin Polymerization and Membrane Physics in Living Cells: Analysis of cell spreading mechanisms

If gifted children are experts in using strategies, why do they experience problems with learning? Why do they underachieve?

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

Can dynamic testing provide us with insight in children’s potential for learning?

Promotor: J.W. van Holten

What is the relationship between outcomes of dynamic testing and cognitive flexibility in young children?

Does a moving hybrid zone leave a genomic footprint?

Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie

John van Noort

What is the optimal investment policy according to which a firm adapts its capacity in a competitive market?

Promotor: W.Th.F. den Hollander

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez

Promotor: Huub de Groot, Co-promotor: Francesco Buda

Cell adhesion signaling

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

This research group is interested in the physics of living cells, especially their cytoskeleton dynamics under defined external stimuli.

Developing methodes to understand the evolution of patches in natural ecosystems

Schemas are knowledge structures that allow us to make efficient judgments about the world without the cost of memorizing every detail of previous experiences. It has long been known that schemas can enhance long-term memory for related information.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

Science, Institute of Environmental Sciences (CML)

PhD Defence

This dissertation shows that dialogical logic constitutes a powerful and flexible general framework for the development and study of various logical formalisms and combinations thereof.

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

What are the principles of genome folding and dynamics in bacteria?

Isis on the Nile. Egyptian gods in Hellenistic and Roman Egypt

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.