PhD Defence

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

The research of our group is centered around dynamical systems, functional analysis and their interplay.

This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.

Promotor: Huub de Groot, Co-promotor: Francesco Buda

An assessment approach that tailors to children’s instructional needs

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

Promotor: W.Th.F. den Hollander

Schemas are knowledge structures that allow us to make efficient judgments about the world without the cost of memorizing every detail of previous experiences. It has long been known that schemas can enhance long-term memory for related information.

Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

John van Noort

Promotor: J.W. van Holten

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Unfolding potential

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Actin Polymerization and Membrane Physics in Living Cells: Analysis of cell spreading mechanisms

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

In this thesis, dynamic testing principles were applied to examine young children's potential for learning. Our studies focused on the role of cognitive flexibility, to further increase our understanding of the cognitive processes involved in children's ability to learn from instruction and feedback,…

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

The local ordering of atoms at the surface of a metallic particle determines its catalytic activity and selectivity. As energy systems of the future will be based on efficient catalytic conversion of small molecules in closed cycles, we study how structural effects of catalysts can be used to our ad…

This book is about the workings of networks of the mobile in Africa, a continent usually associated with the ‘global shadows’ of the world.

What is the optimal investment policy according to which a firm adapts its capacity in a competitive market?

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

What are the principles of genome folding and dynamics in bacteria?

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

This dissertation shows that dialogical logic constitutes a powerful and flexible general framework for the development and study of various logical formalisms and combinations thereof.

For present purposes, it is important to distinguish between an early period of settlement, about 6800-6200 BC, and a late period, about 6200-5800 BC, at Tell Sabi Abyad.

If gifted children are experts in using strategies, why do they experience problems with learning? Why do they underachieve?

Developing methodes to understand the evolution of patches in natural ecosystems

Does a moving hybrid zone leave a genomic footprint?

How citizens and professionals are the key to successful collaboration in the delivery of public services. How do individual characteristics of citizens and professionals influence citizen-professional collaboration in the co-production of public services?

The main question of this research project concerns the extent to which light verbs in West Germanic languages participate in processes of language change.

The map application includes information from old and new buildings archaeological projects. This makes it possible to investigate whether water facilities (wells, cisterns) and waste facilities (cesspits, sewers) were the privilege of Leiden’s wealthy elite in the late 16th and 17th centuries or whether…

Uncovering task solving processes in dynamic testing

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Can dynamic testing provide us with insight in children’s potential for learning?

Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

What is the relationship between outcomes of dynamic testing and cognitive flexibility in young children?

Promotor: Prof.dr. B.R. Katzy, Co-promotor: R. Ortt