Cell adhesion signaling

This research group is interested in the physics of living cells, especially their cytoskeleton dynamics under defined external stimuli.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

What is the optimal investment policy according to which a firm adapts its capacity in a competitive market?

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Schemas are knowledge structures that allow us to make efficient judgments about the world without the cost of memorizing every detail of previous experiences. It has long been known that schemas can enhance long-term memory for related information.

We study the physics of a broad range of biological and soft materials

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

Promotor: Prof.dr. G.J. Kroes

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

This dissertation shows that dialogical logic constitutes a powerful and flexible general framework for the development and study of various logical formalisms and combinations thereof.

This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

On 29 October 2020, the Europa Institute Zurich organized a conference entitled «1. Zürcher Europarechtstag: Europäische Integration, Drittstaaten und (direkte) Demokratie» (1st Zurich European Law Day: European integration, third countries and (direct) democracy

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotor: J.N. Kok, Co-promotor: H.J. Hoogeboom

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

Conference

This research focuses on the (Quantum) Dynamics (QD) of the reactive scattering of H2 from metal surfaces.

The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

What are the principles of genome folding and dynamics in bacteria?

What are the functions of the endocannabinoid system?

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

Isis on the Nile. Egyptian gods in Hellenistic and Roman Egypt

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Here are some systems and infrastructures that are useful to students.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

How citizens and professionals are the key to successful collaboration in the delivery of public services. How do individual characteristics of citizens and professionals influence citizen-professional collaboration in the co-production of public services?