This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.

Cell adhesion signaling

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Promotor: P.D. Grünwald

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

What is the optimal investment policy according to which a firm adapts its capacity in a competitive market?

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

This research group is interested in the physics of living cells, especially their cytoskeleton dynamics under defined external stimuli.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Promotor: Prof.dr. G.J. Kroes

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

This dissertation shows that dialogical logic constitutes a powerful and flexible general framework for the development and study of various logical formalisms and combinations thereof.

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

This thesis consists of five chapters on how to construct prediction sets for different types of data and models in a parametric or nonparametric Bayesian paradigm.

Source: J Cheminform, Volume 7, Issue 1 (2015)

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

The dissociation of CH4 into CH3 + H on a metal surface is the rate determining step in processes which produce hydrogen, such as steam reforming and catalytic partial oxidation. Ultimately, we want to study the dissociation of methane on Ni(111) and Pt(111) quantum mechanically while taking into account…

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotor: Prof.dr. B.R. Katzy, Co-promotor: R. Ortt

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

What are the principles of genome folding and dynamics in bacteria?

Can we tailor catalysts at the atomic scale by means of high-school chemistry and geometry rules?

Isis on the Nile. Egyptian gods in Hellenistic and Roman Egypt

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.

PhD Defence

The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

How citizens and professionals are the key to successful collaboration in the delivery of public services. How do individual characteristics of citizens and professionals influence citizen-professional collaboration in the co-production of public services?

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

What is the effect of a dynamic training in children’s inductive reasoning skills and how is it related to children’s school performances and language development.

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Promotores: F.H.J. Redig, W.T.F. den Hollander

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.