Researchers of the Leiden Institute of Advanced Computer Science (LIACS) have started a 4 year project on developing a system that sends out automatic alerts when components from engines are showing first signs of fatigue.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Supervisor: Gerard van Westen

Unfolding potential

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

In this thesis, dynamic testing principles were applied to examine young children's potential for learning. Our studies focused on the role of cognitive flexibility, to further increase our understanding of the cognitive processes involved in children's ability to learn from instruction and feedback,…

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

An assessment approach that tailors to children’s instructional needs

Alternatives to current practice

Can dynamic testing provide us with insight in children’s potential for learning?

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

Are predictive archaeological maps a reliable tool to play an important role in the spatial planning? One of the goals of this project was to develop best practices for the production and application of the models.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Does a moving hybrid zone leave a genomic footprint?

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

PhD Defence

ASLU 14

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie

A research agenda

Developing methodes to understand the evolution of patches in natural ecosystems

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

The research of our group is centered around dynamical systems, functional analysis and their interplay.

Schemas are knowledge structures that allow us to make efficient judgments about the world without the cost of memorizing every detail of previous experiences. It has long been known that schemas can enhance long-term memory for related information.

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

Actin Polymerization and Membrane Physics in Living Cells: Analysis of cell spreading mechanisms

If gifted children are experts in using strategies, why do they experience problems with learning? Why do they underachieve?

Promotor: W.Th.F. den Hollander

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Promotor: J.W. van Holten

Promotor: Huub de Groot, Co-promotor: Francesco Buda

What is the relationship between outcomes of dynamic testing and cognitive flexibility in young children?

Science, Leiden Academic Centre for Drug Research (LACDR)

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

John van Noort

A new app provides dynamic predictions of survival for patients suffering from soft tissue sarcoma. It was developed by the mathematical Institute research group DASPO, Data Analysis and Survival for Personalised Oncology.

How to come to valid risk stratification of alcohol use disorder?

Research goal: To support the design of technologies (counter-measures and communication measures) for the prevention, interdiction and mitigation of lone actor extremist events (LOEEs), which are hard to anticipate, yet can be highly damaging to local and national communities and therefore must be…