Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.

Theorists have recently made substantial progress in simulating reactive molecule-metal surface scattering but still face major challenges. The grand challenge is to develop an approach that enables accurate predictive calculations of reactions involving electronically excited states with potential…

Multi-Angle Dynamic Light Scattering (MADLS) is a technique that is used to determine properties of particles in suspension. The measurements give the hydrodynamic size distribution of individual particles as well as particle clusters, and assists in the interpretation of the stability of the particles…

A Study of Middle Palaeolithic Riverside Settlements at Maastricht-Belvédère (The Netherlands).

Formulation of biopharmaceuticals

Unfolding potential

Promotor: Huub de Groot, Co-promotor: Francesco Buda

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

The main question of this research project concerns the extent to which light verbs in West Germanic languages participate in processes of language change.

In this thesis, dynamic testing principles were applied to examine young children's potential for learning. Our studies focused on the role of cognitive flexibility, to further increase our understanding of the cognitive processes involved in children's ability to learn from instruction and feedback,…

An assessment approach that tailors to children’s instructional needs

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Can dynamic testing provide us with insight in children’s potential for learning?

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

How can new compounds relieve cancer patients of severe side effects?

Research in the van Exter lab focuses on quantum aspects of light and light-matter interaction. One of our long-term goals is to develop a reliable quantum memory, based on a single emitter in an open micro cavity.

Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

The research of our group is centered around dynamical systems, functional analysis and their interplay.

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

Actin Polymerization and Membrane Physics in Living Cells: Analysis of cell spreading mechanisms

If gifted children are experts in using strategies, why do they experience problems with learning? Why do they underachieve?

Promotor: W.Th.F. den Hollander

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Wolfgang Lüffler

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez

Promotor: J.W. van Holten

The aim of this facility is to accelerate biomedical research by providing access to advanced light and electron microscopy and by sharing expertise about sample preparation, imaging modalities, data storage and image analysis.

What is the relationship between outcomes of dynamic testing and cognitive flexibility in young children?

Does a moving hybrid zone leave a genomic footprint?

This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.

Promotor: Prof.dr. T.J. Aartsma, Co-promotor: R.N. Frese

John van Noort

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Cell adhesion signaling

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

This research focuses on the (Quantum) Dynamics (QD) of the reactive scattering of H2 from metal surfaces.

What is the optimal investment policy according to which a firm adapts its capacity in a competitive market?

Promotor: H.V.J. Linnartz