To maximise your personal development, we ensure tutorials are small-scale and staff members extremely accessible. In year one, you’ll have an average of 12 contact hours, half of which comprise lectures (in English) and the remainder tutorials (optionally Dutch or English).

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

The research addresses the question of “what is the impact of geopolitical changes to the pivot states in the Middle East? With special focus on Turkey, Iran and Saudi Arabia.”

What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?

Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…

On 26 June 2019, Lisa Louwerse defended her thesis 'The EU’s Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement'. The doctoral research was supervised by Prof. C.A.P. Hillion.

On October 31st, Margarita Gulian succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Margarita on this great result.

Leiden University has locations in both Leiden and The Hague.

In this project, the hypothesis that language contact crucially impacts the development of spatial grammar and phonology is investigated.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

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Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

How can we explain that Caribbean small states have the most stable two-party systems in the world, while Pacific small states have either very weak parties or no parties at all? Matthew Louis Bishop (University of Sheffield, UK), Jack Corbett (University of Southampton, UK) and Wouter Veenendaal (Leiden…

Promotor: Prof.dr. R.M.H. Merks

Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…

Developing new drugs is a difficult process. With the aid of artificial intelligence, Pharmaceutical scientist Xuhan Liu has developed methods that can help make drug design cheaper and faster. PhD defence on 15 February.

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Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…

Do natural soundscapes affect migratory decisions of fishes moving up and down rivers and is this process disturbed by vessel sounds?

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

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Medicines are becoming increasingly precise and innovative, but at the same time increasingly expensive. With their innovations, it is up to universities to increase competition, thus causing prices to drop. This is what newly appointed Professor of Biomolecular Analysis Hubertus Irth argues. His inaugural…

Presenting case studies by both senior and emerging scholars, it makes mandatory reading for anyone interested in the challenges of governance, citizenship and development faced by the people of India’s North East.

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Are predictive archaeological maps a reliable tool to play an important role in the spatial planning? One of the goals of this project was to develop best practices for the production and application of the models.

Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?

Make a difference! Join the interdisciplinary Minor Sustainable Development and learn everything about the challenges we are facing and how to find solutions. Discover your sustainable future!

How can we further streamline the development of software for the government? Leiden University and ICTU are to investigate this in a joint research project that was launched on 6 July 2016.

Potential drugs that seem promising in the lab, but don’t show any activity in a person: they cost the industry an incredible amount of time and money. That’s why Indira Nederpelt focuses on a more efficient search for new drugs in her PhD, by determining the kinetics of a potential drug earlier on…

This thesis studies the relationship of the town al-Fusṭāṭ, located at the southern end of the Nile delta in Egypt, and its hinterland in the period between the town’s foundation in A.D. 641 and the arrival of the Abbasids in 750.

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Visualization of biomolecules in living cells by tagging with gold nanoparticles.

Every January, students of the Minor Sustainable Development have the opportunity to put what they’ve learned over the last few months into practice in a choice of exciting and practical courses called Area Studies. This year, for the first time, there was a choice of four locations: The Netherlands,…

Monday 5 September the eighth edition of the interdisciplinary Minor Sustainable Development started. With 65 students coming from more than 20 different disciplines we've a record number of students and backgrounds.

The Edinburgh Medal 2016 had been awarded to both Kevin Govender of the Office of Astronomy for Development (OAD) and the International Astronomical Union (IAU). The award is a recognition for furthering education and technological capacity worldwide through the inspirational science of astronomy. The…

Dirk Huyge (Director) & Wouter Claes (Vice-Director)

They were called 'annoying brats', the group of campaigning scientists who in 1978 founded what is now an internationally acclaimed ecological research institute. Their stories and those of the current staff of the Institute of Environmental Sciences are described in the book 'Forty years of Leiden…

Biodiversity in the Netherlands is having a tough time. Professor of Natural Capital Koos Biesmeijer combines research with practical advice: from the greening of industrial parks to solutions inspired by hi-tech nature. Inaugural lecture 9 March.

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Our childhood years largely determine how we will fare later in life. In the first two decades of our life, our brain is still developing, which is clearly reflected in our behaviour. By studying how the young brain develops and how children behave, researchers can learn important information about…

Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)

The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.

The overall aim of the project is to investigate interests and their development over time in a daily life context, with particular attention for the transition from late secondary to post secondary education, and from late post secondary education to early career.

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?