571 search results for “drug-target binding kinetics” in the Public website
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Matching
The Bachelor's programme in Philosophy: Global and Comparative Perspectives considers it important that you make a conscious and informed decision about your studies. Therefore, we created the Online Matching Module which is designed to help you reach and consolidate this decision.
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Matching
The Bachelor's programme in Linguistics considers it important that you make a conscious and informed decision about your studies. Therefore, we created the Online Matching Module which is designed to help you reach and consolidate this decision.
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Matching
The Bachelor's programme in Arts, Media and Society considers it important that you make a conscious and informed decision about your studies. Therefore, we created the Online Matching Module which is designed to help you reach and consolidate this decision.
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Matching
The Bachelor's programme in English Language and Culture considers it important that you make a conscious and informed decision about your studies. Therefore, we created the Online Matching Module which is designed to help you reach and consolidate this decision.
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When does resistance to toxins evolve in animals? Students publish major review
Does a snake die when it bites its lip? Why will a mongoose survive a scorpion’s sting, but we humans perish? These questions occupied the minds of toxin-enthusiasts and Master’s students Biology Jory van Thiel and Roel Wouters. They collected information from many sources and published their findings…
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Participants
The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).
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This Week’s Discoveries | 14 February 2017
Lecture
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Dr. Dong Guo won the Dutch Medicinal Chemistry prize 2013-2014
On March 27th, 2015 the biannual Dutch Medicinal Chemistry Prize for the best Dutch Ph.D. thesis in the field was awarded to Dr. Dong Guo, a current postdoc researcher in our lab, by the Section of Medicinal Chemistry of the Royal Netherlands Chemical Society.
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New insight brings sustainable hydrogen one step closer
Leiden chemists Marc Koper and Ian McCrum have discovered that the degree to which a metal binds to the oxygen atom of water is decisive for how well the chemical conversion of water to molecular hydrogen takes place. This insight helps to develop better catalysts for the production of sustainable hydrogen,…
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Speed gun for molecules
Detecting molecules with temperature instead of chemical reactions: that’s what scientists from the Leiden Institute of Physics want to do. They are developing a sensor that utilizes special nanoparticles to keep track of certain molecules. In this way, they can for example see how well new drugs do…
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The Ties that Bind: The Role of Cultural Diplomacy in U.S.-European Relations
Debate, StepTalks
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Understanding hydrogen electrocatalysis
Electrocatalysis will play an increasingly important role in future in the transition to more sustainable energy. Thanks to chemist Isis Ledezma Yanez, we now know more about the hydrogen evolution process. PhD defence on the 9th of June.
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Reedijk Symposium 2013 - Guest Lecturers: Dr. Dorothee Kern & Prof. dr. Bernard Dam
On Friday October 25th the fourth annual Jan Reedijk Symposium will be held. The main lectures of the day will be
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Books and films
Leiden University has made history with its many scientific discoveries; a history that is also illustrated in a variety of books and films.
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Dynastic Juniors in Europe and Asia
Subproject of
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Author, Reader, Book: Medieval Authorship in Theory and Practice
This collection brings into conversation several kinds of scholarship on medieval authorship which have tended to remain separate over the last two to three decades, a period of steadily increasing scholarly interest in this topic.
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Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.
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Thomas Schmidt Lab (Single Molecule Microscopy)
Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
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Unveiling the invisible conformational landscape of cytochrome P450
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Redox Interconversion between Metal Thiolate and Disulfide Compounds
In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.
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FitDis!
FitDis! is designed to ease the determination of binding energy and oligomeric state of coiled coil peptides. It allows direct fitting of concentration dependent thermal peptide unfolding curves measured for instance by CD–spectroscopy.
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Public service professionals coping with contrasting demands
Double Bind. Public service professionals coping with contrasting demands. How do public service professionals align their PSM with contrasting demands set by the organizational and social contexts in which they work?
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Guidance documents of the European Commission in the Dutch legal order
On 11 February 2020, Clara van Dam defended her thesis 'Guidance documents of the European Commission in the Dutch legal order'. The doctoral research was supervised by Prof. W. den Ouden and Prof. J.E. van den Brink (UvA).
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Career Services
Do you want to make contact with talented young people at an early stage of their career? Career Services can help you can get in touch with students and young alumni of Leiden University.
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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The Role of Collective Redress Actions to Achieve Full Compensation for Violations of European Union Competition Law
On 23 juni 2019, Zygimantas Juska defended his thesis 'The Role of Collective Redress Actions to Achieve Full Compensation for Violations of European Union Competition Law'. The doctoral research was supervised by Prof. dr. T.R Ottervanger.
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Ties that Bind: Mechanisms and Structures of Social Dependency in the Early Islamic Empire
Conference
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Solvent effects in the electrocatalytic reactions of water
Koper
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Research
The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.
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Indira Nederpelt was awarded best oral presentation at the FIGON Dutch Medicines Days 2014
Indira Nederpelt presented her work at the FIGON Dutch Medicines Days held on October 6 2014 in Ede and provided a kinetic perspective on the characterization of clinically used GnRH peptide agonists.
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Maris Vilums wins LACDR Spring Symposium PhD competition
Maris Vilums was elected as the winner of the annual PhD Competition at the LACDR Spring Symposium, May 23rd 2013, with his oral presentation:
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Superselective bonds light up
Rather than one key and one strong lock, biology often uses tens or hundreds of weaker links to bind parts together, such as cells membranes. This allows for selectivity and also reversibility: the binding can also be undone. Researchers first caught this phenomenon using spheres or colloids, and published…
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Chemical biology of glucosylceramide metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?
- US Diplomacy
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Medicine
The Faculty of Medicine
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Strengthening the EU’s Response Capacity to Health Emergencies: Insights from EU Crisis Management Mechanisms
Despite an increased EU role in the preparedness, monitoring and coordination of health emergencies over the past two decades, Member States’ responses to the first wave of COVID-19 were surprisingly uncoordinated. In light of calls to improve cooperation regarding future health emergencies, this article…
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Proteochemometric modelling coupled to in silico target prediction
An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.
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Compulsory matching
BSc Cultural Anthropology and Development Sociology is a bachelor’s programme with a compulsory matching module.
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The construction of dynasties in Habsburg Spain and Safavid Iran
How did dynastic organization – that it, the employment of non-ruling family members and the development of dynastic traditions and concepts – influence state formation in both Catholic Europe and Muslim West-Asia?
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Zwitterionic oligosaccharides: charging the immune system
How are carbohydrates processed by the immune system? Can carbohydrates be used to trigger T-cells against other conjugated antigens? Can they be used as adjuvants?
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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Limiting Viral Spread: Automated Cyber Operations and the Principles of Distinction and Discrimination in the Grey Zone
Monica Kaminska, Dennis Broeders and Fabio Cristiano have contributed a chapter to the proceedings of the 13th International Conference on Cyber Conflict (CyCon 2021), which gathers 20 articles from the law, technology and strategy domains.
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The immune system in action against cervical cancer
In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.