Since the start of the Corona crisis, several COVID-19 related research and teaching projects were started at LACDR. The computational and teaching activities started right away, as well as a large-scale metabolomics screening program by Thomas Hankemeier’s group. Other experimental activities are still…

The Faculty of Science has presented an infographic with tips and tricks for work stress. The reason for this was the Personnel Monitor 2018, which showed that work pressure is a problem for many employees at the Faculty. ‘It is important to start the discussion about work pressure, and to break the…

On Wednesday 26 October the kick-off event of the research profile area ‘Interaction between Legal Systems 2.0’ (ILS) took place. Speakers explained their understanding of the concept of ILS and the activities and opportunities of ILS 2.0 for the faculty were set out

How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The action plan focuses on addressing key challenges posed by technological developments and trends in biomedical practices

How can collaborative participatory action research by student-teachers and their students enhance student participation, improve educational practices, and generate knowledge about these practices that can be used for improving teacher education as well?

On September 1st, Ingrid van Engelshoven, Minister of Education, Culture and Science, will present the National Action Plan Diversity and Inclusion in Education and Research. The presentation will be held at Leiden University, Campus The Hague.

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

On 12 June 2020 the ESIL Interest Group ‘EU as a Global Actor’ and City Law School London organized a Workshop on ‘The European Union’s External Action and International Law: A View From the Outside’. The event was convened by Jed Odermatt (City Law School) and Ramses A. Wessel (University of Groningen)…

Supervisor: Natalia Ortiz Zacarías

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

A team of five PhD students from Leiden University is in the running for first prize in the Pharmacometrics Skills Competition. In a drug development simulation, they apply their mathematical pharmacological skills to solve clinical problems. On 24 March they will compete in the finals in Orlando, F…

On Thursday 8 June 2017 Melanie Fink, Postdoctoral Researcher at the Europa Institute, participated in the Legal Seminar ‘EU Law and Undocumented Migrants: Defending Rights in the Context of Detention & Deportation’.

Two citizens, together with organisations including Amnesty International, antidiscrimination agency RADAR and the Dutch Section of the International Commission of Jurists (NJCM) have brought legal action against the State. They want the court to put an end to the discriminating border controls of the…

The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

Leiden biotech startup Azafaros has successfully completed a funding round, raising 25 million euros of investments for developing treatments of rare metabolic disorders. The company holds exclusive license to a library of novel patented compounds discovered by experts from Leiden University.

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Can new variants of daptomycin and the polymyxins be found?

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Scholars from the field of science, technology and innovation (STI) policy have often questioned whether there was substantive difference between international STI policy and science diplomacy. This is hard to answer, but at least we can observe that science diplomacy has had great appeal over the last…

Conference

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

The mission in this research group, headed by Ad IJzerman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.