How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Leiden University offers the possibility of pursuing a doctorate in the form of a ‘double doctorate’: a doctorate that is completed simultaneously at two or more universities. This can either lead to a joint doctoral degree (one single diploma awarded by both institutions) or a double doctorate (each…

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

Efficient gene-targeting during meiosis

Identification and characterization of components of DNA repair pathways and their role in Agrobacterium T-DNA integration and repair of CRISPR/Cas induced DSBs.

The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.

Tuesday 12 September 2017 Willy de Heer defended her PhD Thesis

Promotores: H.A. Udo De Haes, P.M. Brakefield

What can the composition and arrangement of urnfield graves tell us about the social and ideological believes of the urnfield period societies?

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

With this thesis the PhD-candidate aims to enrich the body of evidence concerning the relation between stress and health, and the mediating role of (un)conscious perseverative cognitions, which is captured in the extended perseverative cognition hypothesis.

A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

A study of the technology, form, function, and use of pottery from the settlements Uitgeest-Groot Dorregeest and Schagen-Muggenburg 1, Roman Period, North-Holland, the Netherlands

Jan Melissen discusses the political side of the repatriation operation for Dutch citizens stranded abroad in Dutch newspaper 'de Volkskrant'.

Parents may pass anxiety onto their offspring by exposing them to anxious behaviors in novel situations. Just as the parents’ anxious signals lead to anxiety, parents’ confident signals can ward off anxiety in the offspring. This project is seeking a new way to break anxiety transmission in the family…

The Journal of the LUCAS Graduate Conference was founded in 2013 to publish a selection of the best papers presented at the biennial LUCAS Graduate Conference, an international and interdisciplinary humanities conference organized by the Leiden University Centre for the Arts in Society (LUCAS). The…

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

The travel ban and closed borders have had a big impact on our students and staff. Some are stranded abroad, while others are stranded here in the Netherlands. Others again have returned early to their home country. Three personal stories from Wuhan, Leiden and The Hague.

The Journal of the LUCAS Graduate Conference was founded in 2013 to publish a selection of the best papers presented at the biennial LUCAS Graduate Conference, an international and interdisciplinary humanities conference organized by the Leiden University Centre for the Arts in Society (LUCAS). The…

Dr. Willy de Heer defended her PhD Thesis

The Journal of the LUCAS Graduate Conference was founded in 2013 to publish a selection of the best papers presented at the biennial LUCAS Graduate Conference, an international and interdisciplinary humanities conference organized by the Leiden University Centre for the Arts in Society (LUCAS). The…

Ahead of the new Multi-Annual Financial Framework (MFF), the entire European academic world is calling upon Brussels to double the budget for education, research and innovation.

With cancer, the immune system is a double-edged sword: it can attack tumour cells, but can also help them grow and spread. It is a question of harnessing it. This is what Professor Karin de Visser argued in her inaugural lecture on 15 November 2019.

The Journal of the LUCAS Graduate Conference was founded in 2013 to publish a selection of the best papers presented at the biennial LUCAS Graduate Conference, an international and interdisciplinary humanities conference organized by the Leiden University Centre for the Arts in Society (LUCAS). The…

The Journal of the LUCAS Graduate Conference was founded in 2013 to publish a selection of the best papers presented at the biennial LUCAS Graduate Conference, an international and interdisciplinary humanities conference organized by the Leiden University Centre for the Arts in Society (LUCAS). The…

An astonishing twelve students from Leiden University have received a Young Talent Award from the Royal Holland Society of Sciences and Humanities in Haarlem, a record. During the festive ceremony on 25 November, five master students received a Young Talent Graduation Award for their thesis and seven…

Thomas Bakkum en Tom van der Wel, two PhD candidates from the Leiden Institute of Chemistry, have both won poster prizes at the EMBL Chemical Biology Conference 2018 in Heidelberg.

After seven years, the Faculty of Science said goodbye to Geert de Snoo as dean During on 29 August. This happened with a pub quiz, a special edition of Our Talents & Discoveries and no less than two decorations. Take a look at the pictures for an impression!

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Students from the Royal Academy of Art (KABK) can combine their visual arts program from the academic year 2017-2018 with the bachelor program Arts, Media and Society at Leiden University.

Arjan Louwen (MA) will start a PhD research project on the social and ideological aspects of Late Bronze Age and Early Iron Age cremation graves in continental Northwest Europe (1100-500 BC): Breaking and making the ancestors. Making sense of the inconspicuous 99% of urnfield graves.

Almost a hundred students and researchers can study in Leiden or go from Leiden to another university abroad as part of an exchange programme. Fourteen exchange projects have been awarded a subsidy from the EU's Erasmus+ International Credit Mobility programme.

In a promotional video for the SUNRISE initiative, prof. Huub de Groot explains the impact and ideas behind artificial photosynthesis.

The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors

Registration for TAILOR2021 will open soon..

Cameron Mackie has been awarded both the Dissertation prize of the Laboratory Astrophysics division of the American Astronomical Society and the Dissertation prize of the Astrochemistry subdivision of the American Chemical Society for his thesis entitled

On 8 March 2021, International Women’s Day, Vanessa Newby was a panelist at the online discussion ‘Breaking Barriers – Women in Peacekeeping’, organized by A4P WPS Champions Ireland, Germany, South Africa and Bangladesh together with UNSCR 1325 architect, Namibia.

The Dutch chemical industry is regularly in breach of safety legislation. These are the findings of longitudinal research by the Department of Criminology at Leiden University, in collaboration with the Department of Criminology at VU Amsterdam. Over the past ten years, the roughly 400 companies to…

It’s not a regular occurrence at Leiden University: two professors giving their inaugural lecture on the same day. Berna Güroğlu and Ellen de Bruijn specialise in related disciplines: they both research the influence of social context on processes in the brain – Güroğlu in adolescents and De Bruijn…

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

Lecture

Paul Wouters came to the Faculty of Science for a few months to help with organising day-to-day issues after the previous dean left. This has involved rather more than he expected. ‘I can now really understand why every faculty has its own dean.’

A new NMR microscope gives researchers an improved instrument to study fundamental physical processes. It also offers new possibilities for medical science, for example to better study proteins in Alzheimer patients’ brains. Publication in Physical Review Applied.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.