Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Developmental and Educational psychology is concerned with the developmental course and dynamics of cognition, self-regulation, and emotional competence, and the implications for educational and clinical practice.

The Developmental Psychology specialisation of the Research Master’s in Psychology offers a strong theoretical background to provide the varied knowledge-base needed for a thorough understanding of emotional and cognitive development across childhood and adolescence.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

1. Social anxiety and factors determining school success in children. 2. Brain development in relation to cognitive, social and emotional development in adolescence

Science, Leiden Academic Centre for Drug Research (LACDR)

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

The aim of the research master’s programme Developmental Psychopathology in Education and Child Studies is to promote the scientific development of young academics on the path to becoming independent researchers within education and child studies and related disciplines.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Promotor: Prof.dr. G.P. van Wezel

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

New policies, institutional configurations, and state-market relations are emerging outside of East Asia, as new developmental states move beyond the historical experience of East Asian development. Yet, the ‘developmental state’ is still relevant. This book, edited by Jewellord Nem Singh (Institute…

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Which adolescents are more at risk of developing social anxiety disorder later in life?

Dissertation

Trust and reciprocity are two important social behaviors that help adolescents to navigate their social world successfully. In their empirical article in Journal of Research on Adolescence, van de Groep, Meuwese, Zanolie, Güroğlu, and Crone describe the development of trust and reciprocity in adolescents…

Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver

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'Quality Nano' funded research of the Institute of Environmental Sciences to work in Exeter University for 20 working days, which allows the institute to access highly advanced equipment needed for evaluation the toxicity of nanoparticles.

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

It is the dream of Professor Susana Chuva de Sousa Lopes to grow fertile egg cells in the lab. But she says there is a long way to go in her discipline until that is possible. This is the message of her inaugural lecture on 29 June 2020, the first digital inaugural lecture at Leiden University.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Environmental researcher Martina Vijver is over the moon with her ERC Consolidator Grant. This prestigious grant is recognition, she says, of the study of the behaviour and possible toxicity of new nanomaterials in ecosystems.

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

Remko Offringa has been appointed Professor in the field of Plant Developmental Genetics within the Faculty of Science at the Institute of Biology Leiden (IBL) from the 1st of April 2017. Offringa’s research focuses on the role of the plant hormone auxin in controlling plant growth and development,…

What are the developmental pathways to social anxiety (disorder), the causal processes and maintaining factors? How do these factors interact in the development of social anxiety disorder? How can this knowledge be used to design and implement effective preventive intervention programs for youth?

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How can new compounds relieve cancer patients of severe side effects?

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…