735 search results for “developmental toxicity” in the Public website
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High-throughput screening for developmental and reproductive toxicity
Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?
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Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Towards understanding the toxicity of copper nanoparticles in aquatic ecosystems
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Developmental and Educational Psychology
Developmental and Educational psychology is concerned with the developmental course and dynamics of cognition, self-regulation, and emotional competence, and the implications for educational and clinical practice.
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Developmental Psychology (research) (MSc)
The Developmental Psychology specialisation of the Research Master’s in Psychology offers a strong theoretical background to provide the varied knowledge-base needed for a thorough understanding of emotional and cognitive development across childhood and adolescence.
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Developmental and Educational Psychology Lab
What is the relation between brain development and social and cognitive development across childhood, adolescence and adulthood?
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Advanced in vitro models for studying drug induced toxicity
Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price
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Assistant professor in Developmental Psychology
Social and Behavioural Sciences, Psychology
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Evolutionary Developmental Biology of Bitterling Fish
We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…
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Lab facilities Developmental and Educational Psychology
Social anxiety and factors determining school success in children. Brain development in relation to cognitive, social and emotional development in adolescence.
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PhD in Quantitative Cell and Developmental Biology
Science, Institute of Biology Leiden (IBL)
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PHD candidate, Mathematical modeling for prediction of liver toxicity
Science, Leiden Academic Centre for Drug Research (LACDR)
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Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
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Polar auxin transport: translating environmental signals into plant developmental responses
1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…
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Jewellord T. Nem Singh & Jesse Salah Ovadia (Eds.), Developmental States beyond East Asia
New policies, institutional configurations, and state-market relations are emerging outside of East Asia, as new developmental states move beyond the historical experience of East Asian development. Yet, the ‘developmental state’ is still relevant. This book, edited by Jewellord Nem Singh (Institute…
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Quantitative Nanostructure Activity Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic Species
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
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The role of the Arabidopsis AHL15/REJUVENATOR gene in developmental phase transitions
This thesis describes the functional analysis of the Arabidopsis AHL15 gene.
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Changing minds in social anxiety: A developmental network approach to neurocognitive bias modification
Which adolescents are more at risk of developing social anxiety disorder later in life?
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Emotions and the psychosocial development of children with and without Developmental Language Disorder
Dissertation
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Developmental changes and individual differences in trust and reciprocity in adolescence
Trust and reciprocity are two important social behaviors that help adolescents to navigate their social world successfully. In their empirical article in Journal of Research on Adolescence, van de Groep, Meuwese, Zanolie, Güroğlu, and Crone describe the development of trust and reciprocity in adolescents…
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Microbiota-mediated physisorption interactions and particle-specific toxicity
The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.
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Fate, accumulation and ecotoxicity of copper nanoparticles under environmentally relevant conditions
Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.
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Rachel de Jong - Leiden University
Faculteit der Sociale Wetenschappen
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Dissertation Prize for Developmental Psychologist Michelle Achterberg
For her research on social-emotional regulation in children Michelle Achterberg on Wednesday, May 25 2022 received the Dutch Association of Developmental Psychology (VNOP) Dissertation Prize. With her PhD research, she mapped out which mechanisms play a role in social emotion regulation in childhood.…
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Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver
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Childhood precursors of adulthood psychosis
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Remko Offringa
Science
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‘Quality Nano’ funded research for evaluation of the toxicity of nanoparticles
'Quality Nano' funded research of the Institute of Environmental Sciences to work in Exeter University for 20 working days, which allows the institute to access highly advanced equipment needed for evaluation the toxicity of nanoparticles.
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Evelien Urbanus
Faculteit der Sociale Wetenschappen
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Christine Mummery
Faculteit Geneeskunde
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Ili Ma
Faculteit der Sociale Wetenschappen
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Andrea Spruijt
Faculteit der Sociale Wetenschappen
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Control of Western flower thrips through jasmonate-triggered plant immunity
We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.
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grant to further investigate next-generation antibiotics with reduced toxicity
The European Research Council (ERC) has awarded Nathaniel Martin a Proof of Concept (PoC) grant. With it, his group aims to make a dangerous but potent antibiotic less toxic. He receives €150.000.
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‘There’s still much to discover in developmental biology’
It is the dream of Professor Susana Chuva de Sousa Lopes to grow fertile egg cells in the lab. But she says there is a long way to go in her discipline until that is possible. This is the message of her inaugural lecture on 29 June 2020, the first digital inaugural lecture at Leiden University.
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Effect of Nanoparticles on Microbial Catabolism and Community Structure using Biolog techniques
1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?
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Eduard Klapwijk
Faculteit der Sociale Wetenschappen
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Petra Barneveld
Faculteit der Sociale Wetenschappen
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Hinke Endedijk
Faculteit der Sociale Wetenschappen
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Leo de Sonneville
Faculteit der Sociale Wetenschappen
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Wouter Staal
Faculteit der Sociale Wetenschappen
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Maretha de Jonge
Faculteit der Sociale Wetenschappen