Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

When new features are being written into software code, errors can easily be made. This causes bugs, which leads to software appearing later and being more expensive. Michiel Helvensteijn, a PhD student from CWI and the Leiden Institute of Advanced Computer Science, studied how to prevent these kinds…

Four studies on its prehistoric occupation and Holocene geology. With a contribution by Agatha S. Knip, Late Neolithic Skeleton Finds from Molenaarsgraaf (Z.H.).

Quantum Delta NL, a research programme in which Leiden University participates, has been awarded 615 million euros from the National Growth Fund to help develop the Netherlands into a top player in quantum technology.

Zaanen

Global climate change is manifest by local-scale changes in precipitation and temperature patterns, including the frequency of extreme weather events (EWEs). EWEs are associated with a myriad range of adverse environmental and societal consequences, including negative impacts to agriculture and food…

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

Medical Delta has appointed seven professors who will bridge the medical worlds of Leiden, Delft and Rotterdam.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotor: Roeland M.H. Merks

Professor Eline Slagboom has been studying multiple generations of families for over 20 years. She collects data on why some people age healthily and others decline early.

Proton therapy is a new way of treating cancer in which radiation doses are delivered more precisely. This results in less damage to surrounding tissue and fewer side effects. Professor Marco van Vulpen is medical director of HollandPTC in Delft, where the social value of this therapy is studied. Van…

Existing work in probabilistic language modeling can be mostly divided into two categories:

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Hundreds of thousands of Dutch people suffer from pain caused by knee osteoarthritis and the number is rising fast. Prof. Jaap Harlaar specialises in clinical biomechanics. His research is helping improve osteoarthritis treatment. Harlaar has been appointed Medical Delta Professor and now holds posts…

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Prof. Andrea Evers is a health psychologist who studies the role of behavioural factors in health and disease. As a Medical Delta Professor, she is now affiliated with Leiden University, TU Delft and Erasmus University. In that position, she conducts research at the intersection of various disciplines.…

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Promotor: Prof.dr. E. Deprettere

Prof. Marcel Reinders is a data science specialist at Delft University of technology. Using smart algorithms, he searches for links in complex data. For example, he studies patterns in DNA that lead to aberrant cell behaviour. This knowledge will help detect serious diseases such as Alzheimer's and…

Commercial MRI systems cost millions of euros to purchase and require highly trained technicians to operate. Prof. Andrew Webb works on accessible MRI techniques that offer new opportunities in both developed and developing countries. Webb is a professor at the Radiology Department of the LUMC and,…

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Arts and leisure, Arts and leisure

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

... which build on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

On 2 November, nine professors were simultaneously inaugurated as ‘Medical Delta Professor’ at Leiden University, LUMC, Delft University of Technology, Erasmus University and Erasmus MC. With an appointment at a minimum of two of these five academic institutions, they combine technology and healthcare…

Arts and leisure, Arts and leisure

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Yesterday, eight professors were simultaneously inaugurated as ‘Medical Delta professor’, at Leiden University, LUMC, TU Delft, Erasmus University and Erasmus MC. Ariane Briegel, researcher of the Institute of Biology Leiden of Leiden University, also received the double appointment.

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Peter Grunwald

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

ASLU 14

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Classical mathematical models treat space and time as a continuum, while it is sometimes more useful to regard it as granular. Hupkes is studying what this means for a number of important patterns that are often found in computer calculations and in nature.