6 search results for “crispr-cas9” in the Public website
Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
Packaging and accessing DNA molecules
Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.
Plant researchers have been wrong for years about how plant growth and development are regulated, as Yao Xiao pointed out during his PhD project. They overlooked the role of a protein that turns out to be essential, just as it is in the development of animals and yeasts. In plants, it regulates the…
Plant ageing, rejuvenation and life history strategy
What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?
‘Unimportant’ plant gene turns out to be essential
Leiden biologists have shown that a gene present in plants, animals and yeasts does play an important role in plants, although for years the gene was considered unimportant. It turns out the gene plays a crucial role in the development of vascular tissue in plants. Publication in Nature Plants on 11…
Chemical approaches to control the in vivo behavior of nanomedicines
Lecture, Van Leeuwenhoek Lecture on BioScience