In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.

The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Last Thursday, the second ILS Lunch Seminar of this academic year took place. In this successful and well-visited edition, Hans-Martien ten Napel and Mark Leiser both gave very interesting presentations.

Wednesday afternoon April 10th the 2nd edition of the Campus The Hague Career Event took place, organised by Career Service. More than 500 students and recent graduates from three faculties were in Wijnhaven to attend workshops and to network with employers.

Leiden astronomers published two articles on more sustainable astronomy in a special section of the journal Nature Astronomy. Among other things, they calculate that their online conference EAS 2020 consumed three thousand times less carbon dioxide than the face-to-face edition a year earlier. They…

How can zebrafish research help to understand and fight human cancer?

Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Promotor: J.M. Memelink

A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…

PhD defence

Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.

From 18 to 20 May, the Telders International Law Moot Court Competition, organised by the Grotius Centre for International Legal Studies, welcomed 23 European teams to The Hague. The preliminary rounds took place at the Schouwburgstraat building of Leiden University, Campus The Hague. On Saturday 20…

From 24 to 28 June the 7th edition of Leiden University’s annual Frontiers of Children’s Rights Summer School took place in Leiden and The Hague.

The monthly ILS Lunch Seminars bring together colleagues and students from Leiden Law School, by providing an informal setting to hear what researchers from other research programs and institutes are working on. On Thursday 19 April the next edition of the ILS Lunch Seminars takes place, featuring presentations…

Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

PhD defence

How do macrophages and neutrophils contribute to metastatic onset?

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

The Hague Journal of Diplomacy (HJD) closes 2020 with a free publication on the impact of the corona crisis. Thirteen authors on four continents write about 'Diplomacy after Covid19'.

During the Summer School, held at Leiden Law School in Leiden and the Hague, the participants were offered a wealth of lectures and workshops on international and regional children’s rights issues affecting children, families and communities.

Lecture

Lecture, This Week's Discoveries

On Thursday 13 September 2018, the first ILS Lunch Seminar of this academic year took place. Geerten Waling and Michael Klos kicked off the ILS Lunch Seminars-series by presenting on their particular research topics.

With over 200 participants, the first day of the Multidisciplinary International Symposium on Disinformation in Open Online Media (MISDOOM) was a great success. With researchers and practitioners from communication science, media studies, computer science, data science, and journalists and online media…

The International Health Regulations are a set of binding rules which organise the global response to viral outbreaks and other similar transboundary risks to public health.

The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

Promotor: Prof.dr. J. Memelink

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

How does FoxP1 affect auditory perception on a behavioural and genomic level?

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…

Promotor: G.P. van Wezel

Promotor: B. van de Water

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Supervisor: P.J.J. Hooykaas

Can new variants of daptomycin and the polymyxins be found?

How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

By carrying out fundamental research and providing excellent education, universities become a breeding ground for innovation and entrepreneurship.

How can zebrafish research help understanding human diseases?

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.