The main aim of this research is to understand the dynamics of identity within indigenous Caribbean communities as expressed through the practice of intentional cranial modification. A multidisciplinary approach will be applied to achieve this aim, combining current anthropological and sociological…

A mere day after setting foot ashore in the Bahamas on October 13th 1492, Christopher Columbus notes the broad foreheads of the inhabitants of the Americas. These permanently altered cranial shapes are deliberately created through the application of pressure to the head of the infant in the first years…

This study proposes a theory for the encoding of specificity and definiteness in the Chinese nominal based on Cantonese, Mandarin and Wenzhou data.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

People appear to release their feelings of anxiety more quickly when the vagus nerve in the brain is stimulated with a device in the ear. In his doctoral research at Clinical Psychology, Andreas Burger examined new possibilities for treating symptoms of anxiety. PhD defence on 15 May.

Which adolescents are more at risk of developing social anxiety disorder later in life?

Genetically modified organisms (GMOs) could be useful allies in the fight against critical environmental problems. Could because the use of GMOs is strictly regulated at the moment. A Leiden student team is now trying to make these GMOs safer with the aid of an ingenious lock.

A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…

Lecture

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

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This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

Debate

PhD Defence

This thesis investigates the syntax of object marking in Sambaa and the Bantu languages in general, with particular focus on Swahili and Haya, as points of comparison.

This dissertation investigates whether and how gradability is manifested in the nominal domain, as well as the implications this could have for theories of the representation of gradability.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

PhD Defence

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

Conference

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

Examining the therapeutic potential of new semisynthetic lipopeptide antibiotics

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

This research intents to redefine the limits of the electric guitar.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

From basic science to real-world interventions

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

PhD Defence

PhD Defence

In recent years, the issue of mass tort litigation and the fair and efficient settlement and adjudication of mass torts has drawn increasing attention in academic discourse, legal practice and policy debates.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Which intervention technique is more effective in reducing public speaking anxiety in children aged 9 – 12 years, exposure or restructuring cognitions?

Promotor: P. Stevenhagen, Co-promotores: B. de Smit, F. Andreatta

As part of the process of safeguarding the quality of our research, our institutes are audited regularly by a committee of external experts.

Promotor: A. Kros

Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Promotor: P.D. Grünwald

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Conference

Is it possible to successfully design self-assembling nano-scale protein skeletons for use as a vaccine platform?