Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

Source: Eur J Med Chem (2015)

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Source: Mediators Inflamm (2014)

Overview of CML software and data

Supervisor: Indira Nederpelt

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Grants awarded to molecular physiology research

Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.

Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…

Research at the SBC group is comprised of the following research themes:

Here you can find our most recent research publications

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

How to improve the method in quantifying the combined effects of metal-based chemicals?

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

Supervisor: Natalia Ortiz Zacarías

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

This research group is interested in the physics of living cells, especially their cytoskeleton dynamics under defined external stimuli.

On Friday May 3rd 2013 NWO has announced that Dr. Mario van der Stelt, Division of Bio-Organic Synthesis (LIC) and Dr. Laura Heitman, Division of Medicinal Chemistry (LACDR), have been awarded with an ECHO-STIP grant for their project, entitled: “Novel target engagement biomarkers for better drug ca…

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

How do macrophages and neutrophils contribute to metastatic onset?

We are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

The Data-Driven Drug Discovery Network (D4N) is an initiative by researchers from Leiden University and collaborators to join efforts in applying and developing novel techniques from data science to drug discovery and related topics from bioinformatics. The network is embedded in the Leiden Centre of…

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

Andreas Bender, Assistant Professor for Medicinal Chemistry in the Medicinal Chemistry Division of the Leiden / Amsterdam Center for Drug Research, received the "EFMC Prize for Young Medicinal Chemist in Academia" in 2010.

Thomas Bakkum en Tom van der Wel, two PhD candidates from the Leiden Institute of Chemistry, have both won poster prizes at the EMBL Chemical Biology Conference 2018 in Heidelberg.

Drs. Bart Lenselink won the oral presentation at the LACDR Spring Symposium with his presentation “Predicting Drug Potency”.

Chemist Roxanne Kieltyka has received an ERC Starting Grant of 2 million euros. In her lab, she creates gels that mimic the instructive material that supports cells in our body. With the grant, she aims to make these gels stiff and tough, and to create a bio-printed miniature heart ventricle.

Science, Leiden Institute of Chemistry (LIC)

A full overview of BPOC/SSNMR PhD theses.

Overview of Molecular Physiology publications

The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.

Science, Leiden Institute of Chemistry (LIC)

What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?

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In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

Anthe Janssen graduated ‘summa cum laude’ for the master’s programme Chemistry.He used NMR methods to gain insight in the syntheses and behavior of bio sugars. With this knowledge future therapeutics and research tools in hemical and medicinal biology can be developed. Anthe was awarded € 2.500.

This year, Leiden University is organising the 34th Award Ceremony of the World Cultural Council (WCC). Who will be the prize winners this year?

Lecture

Lecture

He presented his PhD research entitled “Kick-starting drug development; translational systems pharmacology using innovative zebrafish experiments and advanced computational modelling”. During his presentation, Rob highlighted the advancements he made in using zebrafish as model in system pharmacolog…

The National Roadmap for Large-Scale Research Facilities programme of NWO enables the building or renovation of research facilities with international allure. Leiden NMR groups take part in the uNMR-NL consortium coordinated by Marc Baldus (Utrecht University) that has been awarded almost 18 million…

Lecture

PhD student Willem Noteborn has investigated supramolecular structures. These can be useful for the loading of medicines and signalling molecules regarding, for example, cellular differentiation. In his thesis, he describes the functioning of these structures.

Leiden University celebrated the annual prize ceremony of the World Cultural Council (WCC) on 8 November with lectures by leading scientists in a festively decorated Pieterskerk.

As a venue, Leiden University is a fitting setting for recognising the outstanding achievements of the award winners and celebrating the inspiration that they bring as role models for encouraging a fairer society by motivating one individual at a time.

An overview of awards and prizes granted to our staff and students in 2018, as well as special appointments and royal distinctions.

The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…