How does invasive hybridization affect threatened native species?

Promotor: Prof.dr. G.R. de Snoo

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Lions in West and Central Africa form a unique group, only distantly related to lions in East and Southern Africa. Biologists at Leiden University confirm this in an article published in Scientific Reports.

In the master’s specialisation Molecular Genetics and Biotechnology at Leiden University students are trained by experts in the areas of molecular biology, microbiology, plant genetics, cellular imaging, animal disease models, and various –omics technologies and the corresponding bioinformatics.

Investigating neurobiological endophenotypes of Social Anxiety Disorder

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

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Lecture

Are traces of fire use detectable in ancient hominin genomes?

This study analyses the prehistory of a northeastern Siberian population, the Sakha, from both a molecular-genetic and a linguistic perspective.

Dina Ishak Bakhoum defended her thesis on 21 January 2021

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.

PhD defence

How do genetic and environmental factors make us vulnerable to depression?

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Promotor: P.M. Brakefield

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

Description of Triple bottom line approach for risk-benefit analysis of genetically modified crops.

This project aims to develop advanced data analysis methods for monitoring and increasing our understanding on biodiversity dynamics in nature reserves such as the Oostvaardersplassen.

PhD defence

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

The applications of studying the early development of insects range from agriculture to material science.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Starting from Husserl’s somewhat controversial claim about the immortality of the constituting subjectivity, this thesis uses the limit-case of death in order to present a phenomenological exploration of the notion of subjectivity and its relationship to nature. It also offers a second-order discussion…

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen), Co-promotor: H.H. de Iongh

Promotores: G.A. Persoon, H.H. de Iongh

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Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

The SNP genotyping line offers flexible genotyping for small and large projects at affordable price and high quality. The use as SNPs as molecular markers is very versatile and can be used for a wide variety of scientific questions ranging from paternity analysis, conservatuion genetis towards QTL…

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

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A sense of security plays an important role in the decision to contribute to nature conservation. Stacey Mac Donald conducted four years of research on the influence of social and political changes and the (post) colonial context on nature conservation in the Dutch Caribbean. On 17 May she will defend…

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

How can we understand the material instability of photographic (mixed media) artworks (1960s - present) from an integrated approach of Art History, Conservation Science and Chemistry in order to preserve these works for the future?

Genetically modified organisms (GMOs) could be useful allies in the fight against critical environmental problems. Could because the use of GMOs is strictly regulated at the moment. A Leiden student team is now trying to make these GMOs safer with the aid of an ingenious lock.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

How can we quantify the density of species within a community through environmental DNA concentrations?