A high resolution, three dimensional view of a molecule provides detailed information that help elucidate its function: by knowing the exact arrangement of atoms in a molecule, we can understand disease, develop drugs to combat them and improve technology.

Can cyclic peptides provide a new generation of antibiotics?

Overkleeft

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen), Co-promotor: H.H. de Iongh

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Promotores: G.A. Persoon, H.H. de Iongh

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

Leiden University, the Faculty of Science, Division Drug Discovery & Safety at the Leiden Academic Centre for Drug Research (LACDR) is looking for a PhD candidate – biology of induced pluripotent stem cells for biochemical modeling of peripheral neurodegeneration

How can we organise society so as to keep our planet habitable for us and for all other life forms around us? To answer this question, Leiden researchers collaborate across disciplines, from biology to data science, and from environmental economy to archaeology.

Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Is it possible for sugar patterns on cells to activate the immune system to combat cancer?

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel, and zinc based on biotic ligand models (BLMs).

Primate and test specialist Jane Goodall paid a visit to the Hortus botanicus in Leiden on 21 May for a ‘meet & greet’. Goodall, a world-famous researcher and nature protectionist, was presented with an orchid named after her and used the occasion to draw attention to the issue of plant protection.…

Study Information, Visit

The number of lions in Kenya is decreasing alarmingly, due partly to the encroaching cities and the development of the countryside. Together with local scientists and inhabitants, Leiden biologists are studying how this decline can be halted. ‘Lions are cleverer than we thought.’

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

The IBL represents the core of modern biological research at Leiden and we interact closely with the other life science Partner Institutes in the faculty:

Does knowledge of environmental performance change farmer's behaviour?

Promotor: Prof.dr. G.R. de Snoo

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…

Farmers on the outskirts of Nairobi National Park protect their livestock using flashing lights on top of the animal enclosures. This system keeps lions away at night. Leiden research has shown that the method is both simple and effective. Publication in PLOS ONE.

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

How can we understand the material instability of photographic (mixed media) artworks (1960s - present) from an integrated approach of Art History, Conservation Science and Chemistry in order to preserve these works for the future?

For a successful implementation of an educational reform, teachers need to regard the proposal as being practical. I used a modular, success-oriented approach to make a context-based reform practical for implemtentation in Duthc biology education. educational reform, modular, teachers, biology, success-oriented,…

Does the presence of Ring-necked parakeets negatively influence feeding and feeding behaviour of native bird species on artificial bird feeders and if so, what are possible solutions?

Do Ethiopian wolves change their diet and foraging strategy in the landscape under different land uses? How land use affect Afro-alpine rodent Communities? How important are Afro-alpine natural resources utilisation for local livelihoods? What is the human perception of conflict in the Afro-alpine a…

How can we quantify the density of species within a community through environmental DNA concentrations?

Paul Brakefield, Professor of Evolutionary Biology at the Institute of Biology in Leiden (IBL) has been awarded an ERC Advanced Grant for his research. He will receive 2.5 million euro to develop his research programme over a period of five years.

In January 2020, Marja Spierenburg joined the FSW as the new Professor of Anthropology of Sustainability and Livelihoods. Let’s get to know her. ‘All my research is basically about nature conservation. I look at areas like national parks, but also at measures aimed at increasing the sustainability of…

In honour of 10 years of cooperation between Kenya Wildlife Service and Leiden University, a Leiden delegation visited Nairobi National Park. To cement the cooperation, a lion in the park was collared and named Karel, which in Dutch literally means ‘free man.’ It will be monitored through satellite…

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Ariane Briegel has been appointed Professor in the fìeld of Ultrastructural Biology within the Faculty of Science at the Institute of Biology from the 1st of December 2015. Her expertise is in using electron cryotomography to study how microbes sense and respond to their environment.

The studies reported in this thesis were situated in the context of an innovation of Dutch secondary school biology curricula. As in any innovation, the practical knowledge of teachers determine the outcomes through the decisions they make while planning and teaching their lessons. The aim of the studies…

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.