Abrupt Climate Change and Cultural Transformation

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

Het proefschrift omschrijft de chemische synthese van fenolische glycolipiden van verschillende mycobacteriën met het doel om deze te kunnen gebruiken voor immunologisch onderzoek.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

This project aims at determining the market value of hydrogen peroxide (HP) that is produced via our electrochemical methods that have been developed as part of the ERC-StG Cu4Energy project.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

Implementation of the new sound synthesis and analysis method in music composition.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

PhD defence

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Within 3 months of the start of the PhD project, your supervisors and you will draw up a Training and Supervision Plan in consultation with you and the other members of the supervision team. 

The document below contains the faculty D&I work plan drawn up for Leiden Law School. This work plan is linked to the University work plan of the D&I Expertise Office.

In the course of your PhD you make agreements with your supervisors concerning your personal development and the supervision you receive. No later than three months after the start of your appointment, these agreements should be recorded in a Training and Supervision Plan. External PhD candidates must…

In the course of your PhD you make agreements with your supervisors concerning your personal development and the supervision you receive. These agreements should be recorded in a Training and Supervision Plan. This plan contains agreements concerning your research, supervision, training, and potential…

From the smallest level of interaction among families and close friends, over the meso-level of schools, shops, churches, religious communities and companies, to the highest level of nation-states and international organisations: Language Policy and Planning (LPP) is everywhere!

At the start of your PhD, you make agreements with your supervisors concerning your personal development and the supervision you receive. These agreements should be recorded in an Education and Supervision Plan.

Most employed and contract PhD candidates at the Faculty of Archaeology follow a 4-year PhD track in a full time position.

Most employed and contract PhD candidates at the Faculty of Humanities follow a 4-year PhD track.

The Ministry of Education, Culture and Science, in consultation with the Netherlands Organization for Scientific Research (NWO), provides funding for the Netherlands National Law Sector Plan, part of the domain ‘Social Sciences and Humanities’.

When should you plan to arrive in the Netherlands? Find out what you should take into consideration when making your travel plans. Also learn about Leiden University's welcome service for newly-arriving international students.

Choosing a master’s programme can be quite a challenge. The following roadmap will help you with making your choice. You will discover which master’s programmes suit your interests and how to best make your choice.

Choosing a study programme at a research university or university of applied sciences can be tricky. There are so many options! Where should you begin? We will guide you step by step through the study choice process, to the study programme that’s right for you.

Despite the value of technology integration for educational equity and quality being emphasized by numerous studies, many gaps exist about how technology integration can be approached in policy plans, implemented in pedagogical practices, and embraced by teachers, students, and parents.