2388 search results for “computational modelling” in the Public website
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Computational modeling of angiogenesis: from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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Computational modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
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Computer models chart extensive Caribbean inter-island networks
The precolonial inhabitants of the Caribbean islands communicated, travelled, and exchanged objects and ideas along an expansive inter-island network. New methods of computer modeling shed light on these networks. Emma Slayton is set to discuss her work on this topic at her Defense on the 12th of Se…
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Simulating the prehistoric use of fire through computer models
Archaeologists often use the percentages of heat-affected stone or bone artifacts found at archaeological sites as a way to determine how frequently fire was used by the inhabitants. Andrew Sorensen and Fulco Scherjon have come up with a computer model called 'fiReproxies' to simulate how fires used…
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations
Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations
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More efficient drug development with the help of computer models
The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…
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Computational Biology
Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.
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Roy de Kleijn
Faculteit der Sociale Wetenschappen
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Saskia Heijnen
Faculteit der Sociale Wetenschappen
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Vera Mekern
Faculteit der Sociale Wetenschappen
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The Landscape Model
This computational approach to the complexity of text comprehension is useful for describing the cognitive processes involved.
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Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
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MODOMA: A computer-simulated laboratory-approach towards language acquisition
The goal of the MODOMA-project is to create a computer model of language acquisition.
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Foundations of Computing (MSc)
The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.
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Franz Wurm
Faculteit der Sociale Wetenschappen
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Computer Systems, Imagery & media
The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.
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Abstract Behavioral Specification: unifying modeling and programming
We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.
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Constructions Emerging: A Usage-Based Model of The Acquisition of Grammar
This dissertation is concerned with the development of grammar. Starting from a usage-based perspective, which holds that children use domain-general learning mechanisms to acquire the grammatical patterns of their mother tongue, Beekhuizen shows how to operationalize various concepts from this tradition…
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Mathematical modelling of adverse outcome pathways
In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.
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Development of Quantitative Nanostructure Activity Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic Species
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
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Preparing MFDEs for the Modelling World
Classical mathematical models treat space and time as a continuum, while it is sometimes more useful to regard it as granular. Hupkes is studying what this means for a number of important patterns that are often found in computer calculations and in nature.
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PhD candidate “Modelling violent conflict”
Science, Leiden Institute of Advanced Computer Science (LIACS)
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Computer Committee
Task of the Computer Committee is to give advice, possibly unsolicited, on ICT matters to the Management Team of LIACS. This includes advice on ICT related policies of the faculty and university, procurement of computer and other machinery, and system administration.
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Brain-Computer Interfacing
Our goal is to develop usable, practical and meaningful Brain-Computer Interfaces to diagnose, restore, repair and enhance functions of the impaired brain.
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Computer Science
PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.
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Mathematical modelling of advanced herbal extraction
Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?
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Stereotyping in Computer Science
LIACS is partner in the project 'Stereotyping in Computer Science.' The project is a collaboration between multiple universities and the Dutch national expert organization on girls/women and science/technology (VHTO), which will investigate the stereotypes that children hold about computer scientist…
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Segments and rules: a comparative study into the computational mechanisms underlying language acquisition
In this project we study the properties of statistical- and rule-learning mechanisms in relation to the acquisition and evolution of language. We ask to what extent these mechanisms are unique to humans - or to human language - by comparing the acquisition of vocal structure in two species: humans (infants)…
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Computed fingertip touch for the instrumental control of musical sound with an excursion on the computed retinal afterimage
Promotor: Prof.dr. S. Haring
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Michael Lew explores how computers can see
Learning how computers can process and describe images just like human beings do. It is one of the key elements of the research of Michael Lew, who sees Deep Learning as a promising way to achieve this goal. On the 1st of January 2021, he was appointed Professor of Deep Learning at the Leiden Institute…
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Control theory methods for quantitative systems pharmacology models
Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.
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Computational facilities
Beowulf clusters looking for new frontiers.
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Computer Science (MSc)
The two-year master’s programme in Computer Science at Leiden University offers seven specialisations ranging from AI to Bioinformatics and Data Science. The programme combines excellent theoretical teaching with possibilities for applied work with industrial relevance.
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Advances in computational methods for Quantum Field Theory calculations
In this work we describe three methods to improve the performance of Quantum Field Theory calculations.
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Under Construction. Cognitive and Computational Aspects of Extended Lexical Units
This dissertation investigates Extended Lexical Units (ELUs), elements that are bigger than just one word and which are stored in the Lexicon.
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Image-based Computational Biology
In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…
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The quantum computer
The worldwide race to the quantum computer is in full swing. This computer can take on computing tasks that we can only dream of today, such as finding proteins that can be used as medicines in seconds flat. Leiden physicists have discovered how the Majorana particle can be used as a building block…
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Handbook of Natural Computing
Natural Computing investigates algorithms and phenonema based on nature to create better and new computer science innovations.
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pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Computer Science (BSc)
We are becoming ever more dependent on automation systems in our daily lives. Computer Science is more than programming; you integrate maths and logic into the development of systems and solutions that can be applied in all fields - from business to healthcare.
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Quantitative biology of polar auxin transport and plant development
The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…
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Computational Drug Discovery
Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…
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Computer support group
The Computer Support group provides dedicated support for the computing infrastructure of Leiden Observatory
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Computability of the étale Euler-Poincaré characteristic
Promotor: S.J. Edixhoven, L.D.J. Taelman
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Computer Science & Economics (BSc)
Met de bachelorspecialisatie Informatica & Economie aan de Universiteit Leiden leer je waardevolle inzichten in de economie te combineren met (programmeer)vaardigheden en kennis uit de informatica.
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Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
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Hai Lin
Science