An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

Promotor: Roeland M.H. Merks

Promotor: Prof.dr. J.N. Kok

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

The precolonial inhabitants of the Caribbean islands communicated, travelled, and exchanged objects and ideas along an expansive inter-island network. New methods of computer modeling shed light on these networks. Emma Slayton is set to discuss her work on this topic at her Defense on the 12th of Se…

Sonja Boas developed new techniques to study vascular growth computationally. The results of her research provide a better understanding into mechanisms behind vascular growth, which is relevant to the development of medical therapies. She defends her thesis 'Computational modeling of angiogenesis'…

Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…

Archaeologists often use the percentages of heat-affected stone or bone artifacts found at archaeological sites as a way to determine how frequently fire was used by the inhabitants. Andrew Sorensen and Fulco Scherjon have come up with a computer model called 'fiReproxies' to simulate how fires used…

The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…

Promotor: M. Ubbink, Co-promotor: G. Siegal

The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…

Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations

With a Vici grant of 1.5 million euros, Professor of Mathematical biology Roeland Merks will look for ways to fix messy and leaky blood vessels in tumours. His research combines mathematical simulations and lab experiments in a unique way.

It is a stormy Sunday afternoon, with gusts of a whopping 110 kilometres per hour. Chemist Teun Sweere defies the enormous headwind on his city bike and wins the NK Headwind cycling after 22,5 minutes. A new highlight follows six months later: his PhD defence (14 June).

Promotor: Prof.dr. E. Deprettere

Although sugars are widely used in biological and medical research, their synthesis is still badly understood. Jeroen Codée has received a Vici grant of 1.5 million euros for systematically studying the production of sugars. ‘I want to genuinely understand the reactions.’

Lecture

PhD Defence

Conference, Workshop

Lecture

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Are predictive archaeological maps a reliable tool to play an important role in the spatial planning? One of the goals of this project was to develop best practices for the production and application of the models.

The goal of the MODOMA-project is to create a computer model of language acquisition.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Lecture

Lecture, Lunch included

Lecture, including drinks and nibbles at the FooBar

Lecture

Lecture

Lecture, Lunch included

Lecture, Lunch included

Lecture

Lecture

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

This dissertation is concerned with the development of grammar. Starting from a usage-based perspective, which holds that children use domain-general learning mechanisms to acquire the grammatical patterns of their mother tongue, Beekhuizen shows how to operationalize various concepts from this tradition…

In this project we study the properties of statistical- and rule-learning mechanisms in relation to the acquisition and evolution of language. We ask to what extent these mechanisms are unique to humans - or to human language - by comparing the acquisition of vocal structure in two species: humans (infants)…

Simulation is a formal scientific method used to develop, compare and test hypotheses (models). In the last few decades the use of simulation has increased dramatically in virtually all scientific disciplines, but is still limited in archaeology due to the technological barrier – coding skills. Starting…

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

This computational approach to the complexity of text comprehension is useful for describing the cognitive processes involved.

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…