What is the connection between materials with weak and strong gravitational interactions?

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Promotor: Prof.dr. S. Portegies Zwart

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

An assessment approach that tailors to children’s instructional needs

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

Unfolding potential

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

In this thesis, dynamic testing principles were applied to examine young children's potential for learning. Our studies focused on the role of cognitive flexibility, to further increase our understanding of the cognitive processes involved in children's ability to learn from instruction and feedback,…

Computational linguistics uses computational methods to help answer linguistics questions across a variety of topics.

Can dynamic testing provide us with insight in children’s potential for learning?

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Inspired and motivated by the chemical challenges associated with the societal energy transition, the Leiden Institute of Chemistry (LIC) aims to reach new fundamental insight into problems from materials science and interface chemistry. In furthering our understanding of the underlying processes, theoretical…

The Leiden Computational Network Science Lab (CNS Lab) researches methods for knowledge discovery from real-world network data.

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie

Promotor: Roeland M.H. Merks

The research of our group is centered around dynamical systems, functional analysis and their interplay.

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…

If gifted children are experts in using strategies, why do they experience problems with learning? Why do they underachieve?

Actin Polymerization and Membrane Physics in Living Cells: Analysis of cell spreading mechanisms

Promotor: W.Th.F. den Hollander

Research in the natural computing group covers theoretical foundations, the development of new algorithms, and interdisciplinary applications of natural computing methods.

We see computer programming as an essential skill. It enables you to be self-sufficient in building tools, processing data, visualizing research output, communicating research results, etc. Moreover, it empowers you to make beautiful things.

Task of the Computer Committee is to give advice, possibly unsolicited, on ICT matters to the Management Team of LIACS. This includes advice on ICT related policies of the faculty and university, procurement of computer and other machinery, and system administration.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Are you thinking about studying Computer Science? Learn more and watch the videos.

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez

PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

Promotor: Huub de Groot, Co-promotor: Francesco Buda

Promotor: J.W. van Holten

Beowulf clusters looking for new frontiers.

What is the relationship between outcomes of dynamic testing and cognitive flexibility in young children?

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Promotor: Prof.dr. S. Haring

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

The two-year master’s programme in Computer Science at Leiden University offers seven specialisations ranging from AI to Bioinformatics and Data Science. The programme combines excellent theoretical teaching with possibilities for applied work with industrial relevance.

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.

Does a moving hybrid zone leave a genomic footprint?