Essays in Archaeology and Assyriology Dedicated to Diederik J.W. Meijer in Honour of his 65th Birthday

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

We study the physics of a broad range of biological and soft materials

Social Aspects of Space in the Configurational Architecture of Frankish Castles in the Holy Land, 1099-1291

The aim of this project is to determine in which cases uncertainty statements resulting from a Bayesian statistical analysis can be trusted.

Promotor: E. Bouwman Co-Promotor: S. Bonnet

Issues such as climate change, the depletion of natural resources or social inequality are too complex to be addressed from a single scientific discipline or by a single country. Leiden University has the expertise to bring the resolution of these enormous problems a small step closer.

Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…

Hetterscheid

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

The Vrijthof excavations (1969-1970)

Promotor: A. Doelman, Co-promotor: V. Rottschäfer

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…

Promotor: Peter Stevenhagen

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

The Leiden Complex Networks Network (LCN2) aims at bringing together scientists from different disciplines, based on a common interest in both theoretical models and empirical analyses of networks and graphs.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

This thesis has three main parts. The first part gives an algorithm to compute Hilbert modular polynomials for ordinary abelian varieties with maximal real multiplication. Hilbert modular polynomials of a given level b give a way of finding all of the abelian varieties that are b-isogeneous to any given…

Promotor: Peter Stevenhagen

This dissertation consists of two parts, with the common theme "Exploration on and of Networks".

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Can we determine the 3D structure of a chemotaxis core complex using single-particle reconstructions via cryo-EM?

What invertebrates are available to feed nestlings in an agricultural landscape of varied complexity?

Investigating the emergence of complex societies in Chalcolithic Cyprus.

Promotor: Prof.dr. M. Ubbink

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.

How can pupils and students learn to get a grip on complex 'swamp situations'? Inaugural lecture in abbreviated form held by prof.dr.ir. Fred Janssen on the acceptance of the post of professor of science education at Leiden University on 19 June 2017.

Professor Frank den Hollander has been awarded a 10-year grant through the NWO Gravitation program, jointly with colleagues from the University of Amsterdam, the Center for Mathematics and Computer Science in Amsterdam, and the Technical University of Eindhoven.

Promotor: H.V.J. Linnartz

Promotor: R. Cramer

Promotor: G.R. de Snoo Co-promotor: C.J.M. Musters

PNAS publication on protein encounter complexes

Promotor: Prof.dr. E. Bouwman