The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…

Essays in Archaeology and Assyriology Dedicated to Diederik J.W. Meijer in Honour of his 65th Birthday

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

Issues such as climate change, the depletion of natural resources or social inequality are too complex to be addressed from a single scientific discipline or by a single country. Leiden University has the expertise to bring the resolution of these enormous problems a small step closer.

Promotor: Peter Stevenhagen

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

The Leiden Complex Networks Network (LCN2) aims at bringing together scientists from different disciplines, based on a common interest in both theoretical models and empirical analyses of networks and graphs.

We study the physics of a broad range of biological and soft materials

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

What invertebrates are available to feed nestlings in an agricultural landscape of varied complexity?

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

Promotor: E. Bouwman Co-Promotor: S. Bonnet

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Hetterscheid

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

The aim of this project is to determine in which cases uncertainty statements resulting from a Bayesian statistical analysis can be trusted.

Social Aspects of Space in the Configurational Architecture of Frankish Castles in the Holy Land, 1099-1291

The Vrijthof excavations (1969-1970)

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: Prof.dr. E. Bouwman

Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink

PhD Defence

Promotor: A. Doelman, Co-promotor: V. Rottschäfer

Promotor: Prof.dr. M. Ubbink

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

PNAS publication on protein encounter complexes

Can we determine the 3D structure of a chemotaxis core complex using single-particle reconstructions via cryo-EM?

Promotor: Prof.dr. M. Ubbink

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

The mechanism of the electrochemical reduction of dioxygen by a mononuclear pyridylalkylamine copper complex was investigated (see picture). It was shown that in neutral aqueous solution dioxygen undergoes stepwise reduction, wherein hydrogen peroxide plays a key role. The rate constants determined…

How can pupils and students learn to get a grip on complex 'swamp situations'? Inaugural lecture in abbreviated form held by prof.dr.ir. Fred Janssen on the acceptance of the post of professor of science education at Leiden University on 19 June 2017.

This book is the first comprehensive presentation of the archaeology of Syria from the end of the Paleolithic period to 300 BC.

The financial system needs complexity theory to predict economic crises like the 2008 meltdown. An international team of scientists, including Leiden physicist Diego Garlaschelli, state this in a paper published in Science on February 19th.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

The ideas in this thesis pay tribute to the French post-structuralist philosophers Jean François Lyotard, Jacques Derrida and Gilles Deleuze & Félix Guattari. In the terms of Deleuze they are rhizomatic structures of ideas that speak about the foundation on which the interpretation of a complex, ‘unheard’…

‘It has never been so easy to set up a Studium Generale series.’ With these words Tilman Grünewald thanked speaker Frank den Hollander, who kicked off the Studium Generale series on complex networks on Monday 20 February.

The building is far from finished, but the former ministry of Internal Affairs is looking more and more like the Academic building for the locations of the University of Leiden in the Hague that it has to become. This week I got a tour behind the scenes of the gigantic project, where I was able to see…