In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

An experimental approach to organic palaeolithic technology

Cell adhesion signaling

Tracking early human behaviour through plant processing and -exploitation.

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

In this thesis, we show that we can use Shimura’s CM theory to explicitly compute the Hilbert class field of any primitive quartic CM field.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

What invertebrates are available to feed nestlings in an agricultural landscape of varied complexity?

How do archaeologists test ideas about the evolution of the modern brain? Veni-researcher Geeske Langejans and then Master student Paul Kozowyk (Leiden University) prepared different Prehistoric glue recipes and tested these for strength in modern test machines at the Delft University of Technology.

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…

Promotor: Peter Stevenhagen

Promotor: E. Bouwman, Co-promotor: S. Bonnet

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

Essays in Archaeology and Assyriology Dedicated to Diederik J.W. Meijer in Honour of his 65th Birthday

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

The Leiden Complex Networks Network (LCN2) aims at bringing together scientists from different disciplines, based on a common interest in both theoretical models and empirical analyses of networks and graphs.

PhD defence

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

We study the physics of a broad range of biological and soft materials

Issues such as climate change, the depletion of natural resources or social inequality are too complex to be addressed from a single scientific discipline or by a single country. Leiden University has the expertise to bring the resolution of these enormous problems a small step closer.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Promotor: E. Bouwman Co-Promotor: S. Bonnet

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Calamus javensis is polymorphic. Morphometry and molecular approach resulted in all names used in the complex are regarded as synonyms of C. javensis except C. tenompokensis, which is retained as a distinct species. One variety is here recognized, C. javensis var. polyphyllus (including C. acuminatu…

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Hetterscheid

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

Promotor: Prof.dr. M. Ubbink

This project develops methods for ensuring the anonymity of individuals in social network data.

The aim of this project is to determine in which cases uncertainty statements resulting from a Bayesian statistical analysis can be trusted.

PhD defence

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Social Aspects of Space in the Configurational Architecture of Frankish Castles in the Holy Land, 1099-1291

The Vrijthof excavations (1969-1970)

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…

The Gulf is a major global destination for migrant workers, with a majority of these workers coming from South Asia. In this book, a team of international contributors examine the often-overlooked complex governance of this migration corridor. Going beyond state-centric analysis, the contributors present…

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée