This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

What are the values that Leiden University cherishes? What does the University stand for and what does it consider important?

The philosophers at the Institute of Philosophy develop new perspectives and insights not only on fundamental philosophical questions, but also on topical and interdisciplinary themes such as secrecy, migration, and climate change.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Since its beginning, Leiden University has been one of Europe's leading international research-intensive universities.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The ultimate aim of the project is to find out whether there are such things as

Students are educated to become academic professionals and responsible and engaged citizens who are internationally and interculturally competent

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

How are links between macro-invertebrate diversity and ecosystem functioning influenced by anthropogenic pressures?

The reintegration of high profile ex-offenders frequently receives great political and public attention. While this attention, more often than not in the form of negative sentiments, may be understandable from a moral perspective, it raises several important questions: how do such offenders reintegrate…

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Supervisor: Anna Vlachodimou

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Due to the fact that the Frisian lands lacked major political centers in the Middle Ages and also because most of its monasteries suffered complete destruction in the second half of the 16th century, relatively few written documents concerning medieval Frisian history have survived. To analyze them…

Politically speaking, the Frisian coastal area constitutes a special case in late medieval Europe since it was not subject to an overlord as it withstood feudalization in the 13th century. Its many sub regions, which were dominated by elites of small noblemen and freeholders, long time succeeded in…

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Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

Promotores: H.W. Lenstra, A. Lucchini

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

The key question addressed in this family study is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable and can thus be found in family members of SAD patients as well. Determination of heritability of these deficiencies is essential for endophenotyping.…

Supervisor: Maarten Doornbos

The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

Unravelling networks of human mobility and exchange of goods and ideas from a pre-colonial, pan-Caribbean perspective

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Promotor: Prof.dr. P. Stevenhagen, Co-Promotor: Dr. J.H. Evertse

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Since my master's thesis on the landed property of the Frisian monasteries in the Middle Ages I am highly interested in the do ut des-aspects of the relation between religious houses and the lay world. Key words here are: property, power, patronage and the role of religious institutions in the 'salvation…

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Abdessamad El Amraoui defended his thesis on 6 Mai 2015.

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

How are digital risk-profiles developed and used in practice?

OSCL is a learning community where anyone associated with Leiden University can learn and talk about open science practices. Example events are Open Science cafés, workshops, and walk-in-hours. The what Open science is an umbrella term for an approach to science that aims to make scientific…

Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros

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The aim of this thesis was to study the link between hearing loss, language skills, and social functioning in deaf and hard of hearing (DHH) children. Sufficient language skills are an essential prerequisite to develop appropriate communication skills, in order to join in conversations with others.…

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Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

How do ideas concerning the academic study of religion relate to the socio-cultural and political context in which they are developed?

PhD Defence

What tools can be applied to measure the output, outcome and impact of science communication efficiently and effectively?

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea