1121 search results for “clinical pharmacology” in the Public website
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Quantitative Clinical Pharmacology
The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…
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Systems Pharmacology
The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.
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Elke Krekels receives Publication Award Dutch Society of Clinical Pharmacology
Krekels received both the Thesis Award and the TOP Publication Award for her thesis 'Size does matter: drug glucuronidation in children'. Her research led to a new dosage regimen of morphine for babies and toddlers. Both prizes were awarded during the scientific meeting of the NVKFB on Friday 11 Apr…
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Systems Biomedicine and Pharmacology (MSc)
The two-years master’s specialisation System Biomedicine and Pharmacology at Leiden university focuses on predicting drug response with computational modelling, developing individualised therapies, and developing innovative analytical tools for personalised health strategies.
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Quantitative Pharmacology
The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacological mathematical and statistical (pharmacometrics) modeling combined with systems biology modeling approaches, to characterize biomarkers for of disease and treatment…
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Clinical applications of (pharmaco)metabolomics
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…
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Quantitative Systems Pharmacology
This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).
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Predictive Pharmacology
Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…
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Systems Pharmacology
The Systems Pharmacology group is headed by Prof. Piet Hein van der Graaf. Systems Pharmacology is the quantitative analysis of the dynamic interactions between drugs and a biological system to understand the behaviour of the system as a whole, as opposed to the behaviour of its individual constituents;…
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
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Predictive pharmacology
The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.
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Systems pharmacology-based optimization of postoperative morphine treatment
Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.
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Systems pharmacology of the endocannabinoid system
What are the functions of the endocannabinoid system?
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Towards predictive cardiovascular safety: a systems pharmacology approach
Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Catherijne Knibbe
Science
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Systems pharmacology of human neuroendocrine disease entities
An important hormone excreting gland in the human body is the pituitary
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Pharmacological resting-state fMRI in aging and dementia
How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?
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Receptor Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…
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Systems pharmacology-based translational drug pharmacokinetics
High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.
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Mathematical analysis of systems pharmacology models
Systems pharmacology aims to apply techniques from systems biology to pharmacological models.
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Clinical Psychology
Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.
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Development of novel metabolomics & systems pharmacology concepts to realize personalized medicine
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.
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Control theory methods for quantitative systems pharmacology models
Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.
- Clinical Psychology (MSc)
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Clinical Neuropsychology (MSc)
The master’s specialisation in Clinical Neuropsychology focuses on fostering clinical and scientific skills based on a solid theoretical background as well as practical training in neuropsychology and (clinical) neuropsychological research.
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Clinical pharmacology of immuno-modulatory biotherapeutics
PhD Defence
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Clinical Neurodevelopmental Sciences
The group Clinical Neurodevelopmental Studies has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders. Focus is on etiology, developmental course, diagnosis, prevention and treatment of neurodevelopmental…
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Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Clinical Technology (BSc)
Medical technology has become an essential part of healthcare. Innovative treatment methods therefore require a new type of medical professional. Someone with medical and technical knowledge, who builds a bridge between technology and patient.
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.
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engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Physics and Engineering Approaches to Biomedicine and Pharmacology
Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.
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Development of novel analytical technologies for metabolomics and systems pharmacology
We are aiming to develop novel technologies to allow better sample preparation or coupling of analytical methods to (i) analyse ultra small samples, (ii) to analyse more metabolites in a quantitative manner and/or (iii) increase the sample throughput.
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Strategy
The division of Systems Biomedicine and Pharmacology focusses on personalised medicine and the development of novel systems-based approaches in translational and clinical pharmacology.
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Lab facilities Clinical Neurodevelopmental Studies
Neurobiological, cognitive and behavioural measurements of normal and abnormal child development.
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Development of novel metabolomics and systems pharmacology methods
We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).
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Lab facilities Clinical Psychology
Psycho-physiological reactions to stress.
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Key publications
Key publications of the Quantitative Clinical Pharmacology group
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Overview
The aim of the division of Systems Biomedicine and Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.
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Pharmacokinetic studies in obese adolescents and obese adults
Pharmacokinetic studies in obese adolescents and obese adults
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Leiden IHL Clinic participates in 1st IHL Clinic International Exchange Programme conference in Israel
From 15 to 20 November 2015 twelve members of the Winter-semester intake of theInternational Humanitarian Law Clinic of the Kalshoven-Gieskes Forum attended and actively participated in an international exchange conference on International Humanitarian Law at Radzyner Law School, IDC in Herzliya, Is…
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Clinical and Health Psychology (research) (MSc)
The research master’s specialisation Clinical and Health Psychology prepares you for a PhD trajectory.
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Clinical pharmacological aspects of mitochondrial function in muscle
PhD Defence
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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From descriptive to predictive pharmacology in children using semi-physiological population modelling: application to hepatic metabolism
Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…
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Research
Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…