The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Krekels received both the Thesis Award and the TOP Publication Award for her thesis 'Size does matter: drug glucuronidation in children'. Her research led to a new dosage regimen of morphine for babies and toddlers. Both prizes were awarded during the scientific meeting of the NVKFB on Friday 11 Apr…

The two-years master’s specialisation System Biomedicine and Pharmacology at Leiden university focuses on predicting drug response with computational modelling, developing individualised therapies, and developing innovative analytical tools for personalised health strategies.

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacological mathematical and statistical (pharmacometrics) modeling combined with systems biology modeling approaches, to characterize biomarkers for of disease and treatment…

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…

The Systems Pharmacology group is headed by Prof. Piet Hein van der Graaf. Systems Pharmacology is the quantitative analysis of the dynamic interactions between drugs and a biological system to understand the behaviour of the system as a whole, as opposed to the behaviour of its individual constituents;…

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

What are the functions of the endocannabinoid system?

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

An important hormone excreting gland in the human body is the pituitary

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

The master’s specialisation in Clinical Neuropsychology focuses on fostering clinical and scientific skills based on a solid theoretical background as well as practical training in neuropsychology and (clinical) neuropsychological research.

PhD Defence

The group Clinical Neurodevelopmental Studies has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders. Focus is on etiology, developmental course, diagnosis, prevention and treatment of neurodevelopmental…

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Medical technology has become an essential part of healthcare. Innovative treatment methods therefore require a new type of medical professional. Someone with medical and technical knowledge, who builds a bridge between technology and patient.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

We are aiming to develop novel technologies to allow better sample preparation or coupling of analytical methods to (i) analyse ultra small samples, (ii) to analyse more metabolites in a quantitative manner and/or (iii) increase the sample throughput.

The division of Systems Biomedicine and Pharmacology focusses on personalised medicine and the development of novel systems-based approaches in translational and clinical pharmacology.

Neurobiological, cognitive and behavioural measurements of normal and abnormal child development.

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

Psycho-physiological reactions to stress.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Key publications of the Quantitative Clinical Pharmacology group

The aim of the division of Systems Biomedicine and Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Pharmacokinetic studies in obese adolescents and obese adults

From 15 to 20 November 2015 twelve members of the Winter-semester intake of theInternational Humanitarian Law Clinic of the Kalshoven-Gieskes Forum attended and actively participated in an international exchange conference on International Humanitarian Law at Radzyner Law School, IDC in Herzliya, Is…

The research master’s specialisation Clinical and Health Psychology prepares you for a PhD trajectory.

PhD Defence

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…