PhD Defence

Promotor: S.M. Verduyn Lunel

PhD Defence

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

PhD Defence

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. D. Tibboel (EMC, R’dam)

The major aim is to determine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) of patients with chronic inflammatory conditions and to develop and evaluate stress management interventions to alter the psychophysiological…

How can the development of constrictions in the blood vessels be reversed?

What are the most important perpetuating factors of chronic fatigue and chronic fatigue syndrome and which interventions are effective in influencing these factors?

The major aim is to develop, evaluate, and implement screening instruments and self-management interventions for patients with chronic conditions in order to optimize health care by tailoring interventions to those patients at risk for adjustment problems.

Development & Disease is one of the four research themes of the Institute of Biology Leiden.

The major aim is to develop, evaluate, and implement disease-generic cognitive-behavioral interventions through the internet in order to optimize tailored health care for patients with chronic somatic conditions.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

The major aim is to unravel the processes underlying psychological factors, such as attention and emotions, influencing the experience of itch and pain in healthy and chronic state.

Bone research provides plenty of detailed data about the health of a person or a group. This data is not only used to reconstruct the past but also to fight disease today.

Promotor: Prof.dr. J. Kuiper

LUMC researchers are looking for factors that point to illness at an early stage.

LUMC researchers are looking for factors that point to illness at an early stage.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

To what extent is “Grip op Pijn” effective and feasible in clinical practice

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.

We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…

Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…

M. Danhof, Co-promotor: O.E. Della Pasqua

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

An important hormone excreting gland in the human body is the pituitary

Focus in skin research

Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

Promotor: J. Kuiper

I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.

Due to the developments around the corona virus, the Translational Winter School on Neuromuscular Diseases is postponed to 2021.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

... which build on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

How are the epidermal lipid pathways involved in health and disease.

The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

PhD Defence

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

The €6.24 million EU-funded research project QSPainRelief has kicked off. The project aims to help patients suffering from chronic pain with novel, personalised combinational treatments and is coordinated by Elizabeth de Lange from the Leiden Academic Center for Drug Research.