In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Are you eager to bring your own questions and curiosity into scientific research? Do the creation of media and use of technology drive your research interests? Could you be a researcher who challenges scientific practice and pushes its boundaries?

At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

There are five institutes at the Faculty of Social and Behavioural Sciences:

A Diachronic Perspective on the Aegean

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Science, Leiden Institute of Chemistry (LIC)

How and why latex bearing plants select specific chemical compounds for eco-chemical interactions with its biotic factors?

Overkleeft

Can cyclic peptides provide a new generation of antibiotics?

This perspective addresses four challenges facing theorists whose aim is to make quantitatively accurate predictions for reactions of molecules on metal surfaces, and suggests ways of meeting these challenges, focusing on dissociative chemisorption reactions of H2, N2, and CH4.

Humanities

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

From 1550 onwards, a great interest in the natural world developed across Europe. This interest was not only stimulated by a growing knowledge of local flora and fauna, but also by the import of numerous exotic animal and plant species. Think, for instance, of researches and collectors like Gessner…

We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Science, Leiden Academic Centre for Drug Research (LACDR), LACDR PhD Portal

In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?

Governance and Global Affairs

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Smart digital infrastructures predicated on myriads of sensors distributed in the environment are often rendered as key to contemporary urban security governance to detect risky or suspicious entities before or during a criminal event takes place. At the same time, they often involve surveillance of…

Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…

In the Biomedical Sciences Management specialisation you gain knowledge and skills in the area of management, business and entrepreneurship with focus on science- and research driven companies. You will combine research in biomedical sciences with different aspects of business studies and learn to build…

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

The master's specialisation Data Science: Computer Science at Leiden University provides students thorough knowledge and understanding of statistical and computational aspects of data analysis, including their application in databases, advances in data mining, networks, pattern recognition, and deep…

What is and should be the role of universities in supporting business? How can business benefit more of relationships with science? And what is the role of policy makers in supporting a productive relationship between science and business? Professor Simcha Jong Kon Chin examines the interactions between…

On 29 June 2017, Carl Mair defended his PhD dissertation “Taking Technological Infrastructure Seriously”. The supervisors are Professor A. Schmidt and Professor G.J. Zwenne.

Our courses embrace developments in technology. Our teachers adapt technological innovations to their discipline, and we keep our teaching up to date on rapid developments in the digital world.

The Faculty of Social and Behavioural Sciences brings together high-quality research and outstanding teaching in the disciplines of cultural anthropology, education and child studies, political science, psychology, science and technology studies, as well as in multidisciplinary approaches.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Many researchers of the Faculty of Science are members of a research school related to their area of expertise. Research schools aim at collaboration of researchers from different faculties in the same university (interfaculty schools) or in different universities (interuniversity schools).

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

Technological advances, such as virtual reality, augmented reality and online assessment platforms are rapidly improving. These tools could potentially contribute to neuropsychological assessment that is more efficient and of higher quality.

Is it possible for sugar patterns on cells to activate the immune system to combat cancer?

While self-driving cars and autonomous weapon systems have received a great deal of attention in media and research, the general requirements of ethical life in today’s digitalizing reality have not been made sufficiently visible and evaluable.

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

Walsh

Science, Leiden Academic Centre for Drug Research (LACDR)

The facility develops and applies advanced, high-throughput methods for genomic research.

The Algorithms and Software Technology (AST) research programme performs fundamental research in the areas of algorithm design and analysis.

How can we connect quantum technology and society for an open debate on its future implications and applications?

The Faculty of Social and Behavioural Sciences brings together high-quality research and outstanding mono- and multidisciplinary teaching.

Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…

Is it possible to formulate a new conceptual foundation for attributing an evaluative role to historiography of science, without relinquishing the historiographic sensitivity of recent work in the discipline?

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.