4,549 search results for “chemical science and technology” in the Public website
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Media Technology MSc Program
Are you eager to bring your own questions and curiosity into scientific research? Do the creation of media and use of technology drive your research interests? Could you be a researcher who challenges scientific practice and pushes its boundaries?
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Teaching
At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Social and Behavioural Sciences
There are five institutes at the Faculty of Social and Behavioural Sciences:
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Tracing Prehistoric Social Networks through Technology
A Diachronic Perspective on the Aegean
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From midplane to planets : the chemical fingerprint of a disk
This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.
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Postdoctoral researcher in Supramolecular Chemistry and Chemical Biology
Science, Leiden Institute of Chemistry (LIC)
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Plant Latex: A Potential Resource of Bioactive Chemicals
How and why latex bearing plants select specific chemical compounds for eco-chemical interactions with its biotic factors?
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Chemical biology of sphingolipids: fundamental studies and clinical applications
Overkleeft
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Chemistry & Chemical Biology approaches toward novel cyclic peptide antibiotics
Can cyclic peptides provide a new generation of antibiotics?
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Towards chemically accurate simulation of molecule-surface reactions
This perspective addresses four challenges facing theorists whose aim is to make quantitatively accurate predictions for reactions of molecules on metal surfaces, and suggests ways of meeting these challenges, focusing on dissociative chemisorption reactions of H2, N2, and CH4.
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Data Steward Social Sciences
Humanities
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Chemical tools to monitor and control human proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Chemical biology of antigen presentation by MHC molecules
MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.
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New History of Fishes. A long-term approach to fishes in science and culture, 1550-1880
From 1550 onwards, a great interest in the natural world developed across Europe. This interest was not only stimulated by a growing knowledge of local flora and fauna, but also by the import of numerous exotic animal and plant species. Think, for instance, of researches and collectors like Gessner…
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Computational approaches to dissociative chemisorption on metals: towards chemical accuracy
We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…
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Chemical functionalization of the graphene surface for electrical and electrochemical sensing application
Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.
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Fully funded Ph.D. position – novel chemical modalities
Science, Leiden Academic Centre for Drug Research (LACDR), LACDR PhD Portal
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Novel chemical tools for target validation in neuroinflammation
In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?
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Assistant Professor (UD) in the field of Earth System Science and Global Challenges
Governance and Global Affairs
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Chemical synthesis of fragments of galactosaminogalactan and pel polysaccharides
The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.
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The synthesis of chemical tools for studying sphingolipid metabolism
Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.
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Theorizing Technologically Mediated Policing in Smart Cities: An Ethnographic Approach to Sensing Infrastructures in Security Practices
Smart digital infrastructures predicated on myriads of sensors distributed in the environment are often rendered as key to contemporary urban security governance to detect risky or suspicious entities before or during a criminal event takes place. At the same time, they often involve surveillance of…
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Single cell technologies for mechanobiology and mechanopharmacology
Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…
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Biomedical Sciences Management
In the Biomedical Sciences Management specialisation you gain knowledge and skills in the area of management, business and entrepreneurship with focus on science- and research driven companies. You will combine research in biomedical sciences with different aspects of business studies and learn to build…
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The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea
Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.
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Data Science: Computer Science (MSc)
The master's specialisation Data Science: Computer Science at Leiden University provides students thorough knowledge and understanding of statistical and computational aspects of data analysis, including their application in databases, advances in data mining, networks, pattern recognition, and deep…
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Inaugural lecture: Where science meets business
What is and should be the role of universities in supporting business? How can business benefit more of relationships with science? And what is the role of policy makers in supporting a productive relationship between science and business? Professor Simcha Jong Kon Chin examines the interactions between…
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Taking Technological Infrastructure Seriously
On 29 June 2017, Carl Mair defended his PhD dissertation “Taking Technological Infrastructure Seriously”. The supervisors are Professor A. Schmidt and Professor G.J. Zwenne.
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Application of technology
Our courses embrace developments in technology. Our teachers adapt technological innovations to their discipline, and we keep our teaching up to date on rapid developments in the digital world.
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Social and Behavioural Sciences
The Faculty of Social and Behavioural Sciences brings together high-quality research and outstanding teaching in the disciplines of cultural anthropology, education and child studies, political science, psychology, science and technology studies, as well as in multidisciplinary approaches.
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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Research Schools
Many researchers of the Faculty of Science are members of a research school related to their area of expertise. Research schools aim at collaboration of researchers from different faculties in the same university (interfaculty schools) or in different universities (interuniversity schools).
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel
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Technological innovation in neuropsychology
Technological advances, such as virtual reality, augmented reality and online assessment platforms are rapidly improving. These tools could potentially contribute to neuropsychological assessment that is more efficient and of higher quality.
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Unraveling cross-presentation pathways using a chemical biology approach
Is it possible for sugar patterns on cells to activate the immune system to combat cancer?
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The Ethos of Digital Environments: Technology, Literary Theory and Philosophy
While self-driving cars and autonomous weapon systems have received a great deal of attention in media and research, the general requirements of ethical life in today’s digitalizing reality have not been made sufficiently visible and evaluable.
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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From molecules to planets: Exploring the chemical heritage of solar systems
Walsh
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Assistant Professor: Metabolomics & Novel technologies (1.0 fte)
Science, Leiden Academic Centre for Drug Research (LACDR)
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Leiden Genome Technology Center
The facility develops and applies advanced, high-throughput methods for genomic research.
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Algorithms and Software Technology
The Algorithms and Software Technology (AST) research programme performs fundamental research in the areas of algorithm design and analysis.
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Linking quantum technology to society
How can we connect quantum technology and society for an open debate on its future implications and applications?
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Research
The Faculty of Social and Behavioural Sciences brings together high-quality research and outstanding mono- and multidisciplinary teaching.
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Animal-free chemical safety testing with new technology ToxProfiler
Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…
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Assessments of Past Science
Is it possible to formulate a new conceptual foundation for attributing an evaluative role to historiography of science, without relinquishing the historiographic sensitivity of recent work in the discipline?
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Inextricable ties between chemical complexity and dynamics of embedded protostellar regions
Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh
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cellular stress pathways for mechanistic understanding of chemical-induced liver injury
Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…
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Statistical Science
The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.