1368 search results for “cells” in the Public website
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Emerging approaches to study cell-cell interactions
The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.
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Cell Observatory
At the Cell Observatory we visualize the dynamic structures of life - from molecule to cell to organism -with the ultimate goal to tackle disease, for instance to reduce the spread of cancer and develop new medicines for tuberculosis. The development of new medicines is one of the core efforts of Leiden…
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Cell Observatory
This page is under construction.
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Cell Therapy
Decision support tool for cell therapy commercialization and business development
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Stem cells as cure
Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.
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3D Cell Environments
Living cells on topographically-controlled substrates: Understanding Cell Motility in a Quasi-3D Environment
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Anisotropy in cell mechanics
Mechanical interactions between cells and their environment play an important role in many biological processes.
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Cell spread and cell migration in 3D gels
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Towards Biosolar cells
BioSolar Cells is a five-year research project in which ten knowledge institutions and 45 private industries work together.
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Streptomyces as cell factories
We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.
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From Cells to Organisms (MSc)
The master's specialisation From Cells to Organisms at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.
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Cancer cells: A closer look
What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.
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Nanowire based Tandem Solar Cells
In this project innovative technology for photovoltaics cells is developed and analysis of ecological and health related risks are explicitly accounted for.
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Centre for Microbial Cell Biology
The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.
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RESTORING T-CELL HOMEOSTASIS BY IN VIVO MANIPULATION OF DENDRITIC CELLS
The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…
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Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
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Cell adhesion signaling: dynamics, migration, and metastasis
Cell adhesion signaling
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Lisanne Rens - The maths behind our cells
Using mathematics to unravel biological processes: mathematician Lisanne Rens built a mathematical model to study the mechanisms that drive tissue shaping. Her model bridges different biological scales, from molecules to cells to entire tissues. ‘It’s fascinating how cells, that behave as individual…
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Stem cells suppress rejection in organ transplants
Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.
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Stromal cells suppress immune response symptoms
A new therapy for the serious Graft-versus-Host disease
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Single gold nanorods in live cells
Visualization of biomolecules in living cells by tagging with gold nanoparticles.
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Modulating the behaviour of pancreatic tumour cells
Promotores: Prof.dr. M.K. Richardson, Prof.dr. H.P. Spaink
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager
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Cell Wall Dynamics in Aspergillus niger
This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.
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Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Spreading the Fire: Why is Pyroptotic Cell Death Contagious?
The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…
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Taking control of charge transfer: strategic design for solar cells
Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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From islet transplants to stem cell therapy for diabetes patients
Stem cells can be differentiated into insulin-producing cells.
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The mechanism of Agrobacterium-mediated transformation of eukaryotic cells
We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.
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Regulation of nanoparticle biodistribution by scavenger endothelial cells (SECs)
A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…
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Making a field of interpretation for biosolar cells
This project investigates the role of art in the public and academic debate on biosolar energy
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Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Knowledge of DNA repair in the fight against tumour cells
What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.
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Characterization of Cell-based medicinal products (CBMPs)
Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…
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Supramolecular materials: from biosensors to cell delivery devices
The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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Regulation of enzyme production in fungal cell factories
Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.
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Off the wall: characterisation and exploitation of a cell wall deficient life style in filamentous actinomycetes
Almost all bacteria are enveloped by a cell wall that provides cellular protection.
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Vaccination against atherosclerosis; induction of protective CD8 T-cells through immunization
Atherosclerosis, in particular rupture of atherosclerotic plaques, is the underlying cause of most heart attacks or strokes and is the leading cause of death worldwide.
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CD8+ T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
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Towards treatment of liver fibrosis; cells, targets and models
PhD Defence
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Professor in Stem cell technology for innovative drug research
Science, Leiden Academic Centre for Drug Research (LACDR)
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Squaramide-based supramolecular materials for 3D cell culture applications
PhD Defence
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.