57 search results for “cell-matrix adhesions” in the Public website
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Regulators of integrin α6β4 function
This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.
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Reconstructing adhesives
An experimental approach to organic palaeolithic technology
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Composition and function of integrin adhesions
Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Mechano-transduction mediated by integrin-based adhesion complexes: integration of cytoskeleton and adhesion dynamics
In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.
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Cell adhesion signaling: dynamics, migration, and metastasis
Cell adhesion signaling
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What’s in a plant?
Tracking early human behaviour through plant processing and -exploitation.
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Erik Danen
Science
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Multiscale mathematical biology of cell-extracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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Composition and function of integrin adhesions
PhD defence
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Cancer Drug Target Discovery
We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Reconstructing adhesives: An experimental approach to organic Palaeolithic technology
PhD defence
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Research
An overview of the research at the Cancer Dug Target Discovery group.
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Software
Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements
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Mechano-transduction mediated by integrin-based adhesion complexes
PhD defence
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Cellular Forces: Adhering, Shaping, Sensing and Dividing
Promotor: Prof.dr. T. Schmidt
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Glue recipes and prehistoric brainpower
How do archaeologists test ideas about the evolution of the modern brain? Veni-researcher Geeske Langejans and then Master student Paul Kozowyk (Leiden University) prepared different Prehistoric glue recipes and tested these for strength in modern test machines at the Delft University of Technology.
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Dynastic Juniors in Europe and Asia
Subproject of
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Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Systematics, Epidermal defense and Bioprospecting of Wild Orchids
This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.
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hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
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Cancer Drug Target Discovery
In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…
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Cellular Actin Dynamics
Actin Polymerization and Membrane Physics in Living Cells: Analysis of cell spreading mechanisms
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3D Cell Environments
Living cells on topographically-controlled substrates: Understanding Cell Motility in a Quasi-3D Environment
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The construction of dynasties in Habsburg Spain and Safavid Iran
How did dynastic organization – that it, the employment of non-ruling family members and the development of dynastic traditions and concepts – influence state formation in both Catholic Europe and Muslim West-Asia?
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Leiden Academic Centre for Drug Research
The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.
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Neanderthals knew what they were doing when it came to making the oldest known glue
Adhesives are an incredibly important part of every day life. They help hold together everything from shoes and mobile phones to satellites in space. But we didn’t invent adhesives: Neanderthals did, to make handles for stone tools over 191,000 years ago. Leiden researchers now found that Neanderthals…
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Paul Kozowyk (Material Culture Studies) wins 2nd/3rd prize Leiden University Thesis Awards
Leiden University 2016 thesis awards were awarded to Kaspar Pucek (History), Mariska Meijer (Bio Medical Sciences) and Paul Kozowyk (Archaeology).
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Doris Heinrich Lab (Biophysics of Cellular Dynamics)
This research group is interested in the physics of living cells, especially their cytoskeleton dynamics under defined external stimuli.
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Intracellular Transport
Bead microrheology: Analysis of active and passive transport in living cells
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Paul Kozowyk Archon PhD
Paul Kozowyk has received one of the Archon PhD positions with his research proposal Sticking around: identification, performance and preservation of Palaeolithic adhesives.
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Cells ‘walk’ to firm ground
A new mathematical model may explain how body cells get their shapes and what makes them move within a tissue. The model provides fundamental knowledge for applications in tissue engineering, amongst other things. Publication in open-access journal iScience.
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How Neanderthals made the very first glue
The world’s oldest known glue was made by Neanderthals. But how did they make it 200,000 years ago? Leiden archaeologists have discovered three possible ways. Publication in Scientific Reports, 31 August.
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PhD student, to identify and characterize inhibitors of carbohydrate modifying enzymes to generate a new type of anti-viral molecule
Science, Leiden Institute of Chemistry (LIC)
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Five ERC Starting Grants for young Leiden University researchers
The European Research Council has awarded a Starting Grant to five early career scientists from Leiden University. They received funding up to 1.5 million euros to further expand on their research subject.
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Development: The Intra- and Extracellular Networks that Coordinate Collective Cell Behavior
Lecture
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From stickers to spacecraft parts: students discover the diversity of the Bio Science Park
On Friday 30 November 2018 more than 70 students became acquainted with the large range of companies that Leiden Bio Science Park has to offer. In addition to the companies with eye-catching façade names along the cycling route to the faculty, like CHDR, BaseClear and Astellas, there is much more to…
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Neanderthal glue from the North Sea
A flint tool covered with a tar-like substance has turned out to be a top scientific find. Research by a Dutch team of scientists showed the find to be a piece of birch tar that was extracted 50,000 years ago by Neanderthals using complex techniques. The tar was used as an adhesive to make it easier…
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Erik Danen appointed as Professor of Cancer drug target discovery
As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.
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Collaborative and effective drug development
There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…
- Publication highlights
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Awards and Grants 2019
An overview of awards and prizes granted to our staff and students in 2019, as well as special appointments and royal distinctions.
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Ensnaring tumours in their own web
Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.
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A fatty solution for eczema
Pharmacologist Walter Boiten developed a new method to determine the amount of lipids in a person's skin. With this method he tested the effects of a new cream he developed for eczema patients. The first results are promising. Boiten defends his dissertation on 15 January.