.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Joost Beltman (LACDR, Leiden University) has provided novel insights in the way T cells migrate towards virus-infected cells. This was accomplished by a combination of experimental research in the group of Ton Schumacher (Dutch Cancer Institute, NKI) and computer simulations in collaboration with Rob…

Cell adhesion signaling

Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…

A team led by Erik Danen from the Leiden Academic Centre for Drug Research has received a 3 million euros NWO Science Groot grant to unravel the first steps of metastasis. Danen will work together with biologists and theoretical and experimental physicists from Dutch Universities. ‘Understanding these…

Lecture

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.

Living cells on topographically-controlled substrates: Understanding Cell Motility in a Quasi-3D Environment

Control of Living Cells by Magnetic Fluorescent Nanoparticles

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements

Lecture, Leiden Interdisciplinary Migration Seminar (LIMS)

Postcolonial Displacements explores the multiple ways in which migration in South Asia contributes to the imagining, questioning, subverting and reframing of territories, nations and communities. The project focuses on the contested fringes of the politically divided South Asian subcontinent, across…

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Discovery of metastasis promoting candidate drug targets

Historical migration studies have long focused primarily on the European and Atlantic worlds. In this programmatic and long term project, we aim to broaden the perspective to include the full migration experience of the non-Western world.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Globalization, migration, technological innovation and climate change pose challenges to citizens in European countries. These challenges test the limits of cross-national and cross-generational solidarities, touching upon the very foundations of governance and society. This research program aims at…

Migration and Mobility in the Early Roman Empire by Luuk de Ligt and Laurens E. Tacoma (Eds.)

Deze bundel is de tweede in de reeks Studies in Global Migration History en past als zodanig binnen het al langer lopende internationale project ‘Global Migration History’, dat beoogt dit nieuwe onderzoeksveld verder te ontwikkelen.

Bij Cambridge University Press is in september 2011 'The Encyclopedia of Migration and Minorities in Europe. From the 17th Century to the Present' verschenen. Op dinsdag 29 november 2011 vindt een symposium rondom deze encyclopedie plaats in het Snouck Hurgronje Huis te Leiden.

The proposed project evaluates how the vulnerability of migrant men and women was constructed in political, public and media discourses, and how differences in the constructed vulnerability influenced the decision to migrate, the migration process, and the subsequent settlement process.

The research programme Cities, Migration and Global Interdependence 1350-2000 (CMGI) focuses on urbanisation, migration, and economic development in a comparative and global context.

From colonial times through to the present day, large numbers of Javanese have left their homes to settle in other parts of Indonesia or much further afield. Frequently this dispersion was forced, often with traumatic results.

The Encyclopedia of Global Human Migration provides a complete exploration of the prominent themes, events, and theoretical underpinnings of the movements of human populations from prehistory to the present day.

This book sheds new light on domestic forced migration by examining the experiences of American-born slave migrants from a comparative perspective.

Subproject of "Differences that make all the difference. Gender, migration and vulnerability (migration to the Netherlands 1945-2005)"

This project aims at investigating the multidirectional effects of forced and voluntary forms of migration in the ancient Near East.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

This volume is pubished in the IMISCOE-AUP Series and edited by Marlou Schrover and Deirdre M. Moloney.

Theoretical physicist Luca Giomi receives a 2 million euro ERC Consolidator Grant for research into flowing cells in a strange hexatic phase, which is half fluid, half solid.

In February 2014, the Swiss voting population accepted a constitutional initiative that aims at limiting migration through quota and, in the field of employment, national preference.

How do we define the works of a film director whose films cross many established boundaries at once?

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

Promotores: A.H. Meijer, H.P. Spaink

As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.

This research group is interested in the physics of living cells, especially their cytoskeleton dynamics under defined external stimuli.

The central aim is to systematically study differences in crime patterns and social control between migrants and non-migrants in early modern Frankfurt am Main.

Moving Romans offers an analysis of Roman migration by applying general insights, models and theories from the field of migration history.

To what extent was labour-induced migration important to the functioning of the towns and cities of Roman Italy?