174 search results for “cardiac surgery” in the Public website
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Multi-modality imaging in ischemic heart disease, arrhythmia and cardiac-mechanics
PhD Defence
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Towards predictive cardiovascular safety: a systems pharmacology approach
Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski
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Threat and Challenge in Social Contexts
How can cardiovascular responses index challenge and threat motivational states? How do challenge and threat states shape, and are shaped by, social relations?
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Activity-based protein profiling in drug discovery
In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.
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Preoperative blood management in colorectal cancer surgery: the controversial role of iron
PhD Defence
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Implementing patient safety in laparoscopic surgery: quality assessment and process analysis
PhD Defence
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Fluorescence-guided surgery: Clinical translation of targeted and non- targeted dyes
PhD Defence
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Image guided surgery: clinical validation of lesion identification technologies and exploration of nerve sparing approaches
PhD Defence
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Near-infrared fluorescence imaging with indocyanine green in vascular surgery
PhD Defence
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Fluorescence-guided cancer surgery, using clinical available and innovative tumor-specific contrast agents
PhD Defence
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Optimizing Breast Reconstructive Surgery in the Netherlands Using Clinical Audit Data
PhD Defence
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Short-term Pre-operative Dietary Restriction in Vascular Surgery
PhD Defence
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diagnosis and prevention of blood loss in coronary artery bypass surgery
PhD Defence
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Anja Rüten-Budde
Anja Rüten-Budde is our Mathematical Institute’s nominee for the C.J. Kok Jury Award 2020.
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Healthcare robots and AI
Healthcare robots and AI is a project that investigates the legal and regulatory aspects of healthcare robot and Artificial Intelligence (AI) technologies
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Strategic Partnerships/ Cooperation Partnerships
Erasmus+ Strategic Partnerships (Key Action 2) are transnational projects designed to develop and share innovative practices and promote cooperation, peer learning, and exchanges of experiences in the fields of education, training, and youth. There are two kinds of Strategic Partnership; those supporting…
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Innovation in treatment and care
Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…
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evidence-based dosing in morbidly obese patients before and after weight loss surgery
PhD Defence
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Determining the kinetic profile of ENT1 inhibitors
Supervisor: Anna Vlachodimou
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Medicine/Leiden University Medical Center
We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.
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CD8+ T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Three-dimensional in-vivo intra-cardiac vortex flow from 4D Flow MRI: Quantification, automatic identification and association with energy loss
PhD Defence
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eLaw publishes in Nature
Researchers of eLaw, the Center for Law and Digital Technologies at Leiden University, published their research in Nature Machine Intelligence. The publication, written by Eduard Fosch-Villaronga, Pranav Khanna, Hadassah Drukarch, and Bart Custers, focuses on the legal and regulatory implications of…
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Imaging & Intervention (MSc)
This specialisation focuses on two important trends in health care: early diagnosis and developing the most targeted patient-specific treatment possible with the shortest possible recovery time and minimal side effects.
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Systems pharmacology-based optimization of postoperative morphine treatment
Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.
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Boudewijn Lelieveldt: 'AI can help, but not replace, doctors and other healthcare providers'
‘I would never want to be treated by a computer,’ says Boudewijn Lelieveldt, Head of Radiology at the Laboratory for Clinical and Experimental Image Processing and Medical Delta professor in the Bioinformatics group at Delft University of Technology. No matter how intelligent a system, we have to continue…
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Light-activatable ruthenium-based anticancer prodrugs
Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?
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Two grants for LUMC on AI for precision diagnostics
Two AI research projects receive funding; one in the field of oncology and one in the field of cardiology.
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Key publications
Key publications of the Quantitative Pharmacology group
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Personalised sarcoma care: Leiden mathematicians develop a prediction app
The DASPO-group for data analysis and survival in personalized sarcoma at the Mathematical Institute has developed an app that provides personalised predictions for patients suffering from soft tissue sarcomas. Due to the aggressive nature of such tumors, the prognosis for such patients is poor, even…
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Inhibition of MicroRNA-494 reduces carotid artery atherosclerotic lesion development and increases plaque stability
Publication by: Anouk Wezel, Sabine Welten, Wida Razawy, Max Lagraauw, Margreet de Vries, Eveline Goossens, Martin Boonstra, Jaap Hamming, Ekambar Kandimalla, Johan Kuiper, Paul Quax, Yaël Nossent and Ilze Bot. Annals of Surgery. 2015;262:841-848.
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Three VICI grants for Leiden researchers
Three Leiden researchers have been awarded a prestigious Vici grant by the Netherlands Organisation for Scientific Research (NWO). They each receive 1.5 million Euro to develop their own research project in the coming 5 years.
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Key publications
Key publications of the Quantitative Clinical Pharmacology group
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Michiel Hogerheijde, professor by special appointment of Instrumental Astronomy UVA
Dr M.R. Hogerheijde (1971) has been named professor by special appointment of Instrumental Astronomy at the University of Amsterdam (UvA)’s Faculty of Science. The chair was designated on behalf of the Society for the Promotion of Physics, Medicine and Surgery.
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Dynamic personalised sarcoma care: implementation of a mathematical prediction app in the clinic
A new app provides dynamic predictions of survival for patients suffering from soft tissue sarcoma. It was developed by the mathematical Institute research group DASPO, Data Analysis and Survival for Personalised Oncology.
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New Medical Delta professors mean boost for health and technology research
Five of the new Medical Delta professors who now hold an appointment at multiple institutions are affiliated with Leiden University/LUMC. They are psychologist Andrea Evers and four LUMC professors.
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Plastic surgeon Diederik Hofstede: ‘I like small scale'
After studying medicine in Leiden, Diederik Hofstede specialised in plastic surgery. 'I was attracted by its creativity and I enjoy working with my hands.' Cosmetic surgery is just 5% of the work.'
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Five Leiden researchers elected as members of KNAW
Five Leiden researchers have been nominated as members of the Royal Netherlands Academy of Arts and Sciences (KNAW).They will be inaugurated on 16 September.
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LACDR excels at the FIGON Dutch Medicine Days
The Leiden Academic Centre for Drug Research (LACDR) received no less than three awards during the Figon Dutch Medicine Days. Bas Goulooze won the PhD Prize for best PhD candidate, Natalia Ortiz Zacarías and Huub Sijben both received a poster prize. ‘Scientists must be able to communicate their research…
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Different medication dosage for morbidly obese patients
PhD research recently completed by pharmacologist Margreke Brill shows that morbidly obese patients should be given a different dosage of the drugs Cefazolin and Midazolam. This could also apply to other drugs such as anti-cancer drugs as well as antibiotics and Margreke Brill is advocating a change…
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PhD student (1.0 FTE) "Personalized rewards of lifestyle changes in cardiovascular diseases"
Social and Behavioural Sciences, Psychology
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Stress-related prolonged cardiovascular activity: The impact and changeability of stressful cognition without awareness
The research question is that unconscious perseverative cognition (UPC) is responsible for a considerable part of cardiovascular (CV) activity that occurs even in the absence of threats and other stressors that one may encounter in one’s daily life.
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PhD candidates on the Mathematical Modeling of Cardiovascular Development
Science, Mathematical Institute (MI)
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Molecular Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…
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Cancer Therapeutics and Drug Safety
In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…
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Tracers that light up tumours help surgeons
How do surgeons avoid causing nerve damage or leaving cancerous cells behind? An interdisciplinary research group at the LUMC hopes to improve operations and make them less invasive with the aid imaging techniques. They are working with medical companies to make these techniques widely available.