This thesis describes the importance of being able to control the selectivity of potential drug candidates.

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

One of the current research projects funded by the profile area Political Legitimacy is the research group From Disorder to Order: Conflict and the Resources of Legitimacy.

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D1.2 reports on the findings of an analysis of framework conditions relevant in the context of the data economy from a legal, a socio-economic and a technological perspective. The analysis is a key foundation for the creation of an initial, heuristic model of the European data economy. The deliverable…

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

Source: ChemMedChem (2015)

Law

BACKGROUND: Explant human skin equivalents (Ex-HSEs) can be generated by placing a 4mm skin biopsy onto a dermal equivalent. The keratinocytes migrate from the biopsy onto the dermal equivalent, differentiate and form the epidermis of 1(st) generation Ex-HSEs. This is especially suitable for the expansion…

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Dr. Joris Larik, Assistant Professor of Comparative, EU and International Law at LUC The Hague, has co-authored a report entitled 'UN 2.0: Ten Innovations for Global Governance 75 Years beyond San Francisco'.

Methods for accurately computing the interaction of molecules with metal surfaces are critical to understanding and thereby improving heterogeneous catalysis.

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

In a publication in Science, Noam Zelcer from the Division of Biopharmaceutics describes a previously unrecognized pathway to regulate LDL-cholesterol levels. He is also able to modulate this pathway. This opens the possibility for complementing and improving the efficacy of statins: A class of drugs…

Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…

Supervisor: Indira Nederpelt

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The mission in this research group, headed by Ad IJzerman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

Science, Institute of Biology Leiden (IBL)

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Science, Leiden Institute of Chemistry (LIC)

Promotores: Prof.dr. M. Franx & Prof.dr. P.G. van Dokkum (Yale University)

Dr. Gruni published an article on the impact on sustainable development in the EU Common Commercial Policy of recent Opinion 2/15 CJEU on the Global Trade and Customs Journal.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

The narrow but long stretched stript of Frisian land along the North Sea was already occupied before Roman times. However, man repeatedly suffered setbacks when he tried to extend his living space, both in the tidal marshes and the peat area south of them.

Humanities

Here you can find our most recent research publications

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…

The map application includes information from old and new buildings archaeological projects. This makes it possible to investigate whether water facilities (wells, cisterns) and waste facilities (cesspits, sewers) were the privilege of Leiden’s wealthy elite in the late 16th and 17th centuries or whether…

In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.