Sweetie 2.0 is a research project commissioned by Terre des Hommes on online child sex tourism and criminal law.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Advanced fluorescence microscopy techniques have revealed how steroid receptors move inside the nucleus. The results were published by a team from Leiden University and the Erasmus Medical Center in Rotterdam, led by IBL-researcher Marcel Schaaf.

In the Wijnhaven building is room 2.64, designed to facilitate collaborative work. Circular tables hold up to 8 people. The room has 3 separate projection points which can be cast using a wireless USB dongle and desktop application. This room is listed in ZRS and can be booked (for certain faculties)…

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

On the second floor of the Lipsius building is room 2.17, an active classroom designed with a capacity of 24 for active, group-based classwork. From 2019, the room will be part of the ZRS system and can be booked by the Humanities faculty and Humanities Service Desk.

Social media in the Chinese context. To what extent do these mobilise people to act, and what kind of social media are more influential than others?

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency. That is what research by PhD candidate Julia Hillger shows. She defends her PhD dissertation Take it Personal on Thursday 7 December.

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

Large-scale excavations at Neumark-Nord 2 (Germany), a very rich Middle Palaeolithic site with excellent preservation of organic (faunal and floral) remains and lithics in fine-grained lake deposits, dating to about 125,000 years ago.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Analecta Praehistorica Leidensia is the annual journal of the Faculty of Archaeology (formerly the Institute of Prehistory), Leiden University.

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.

How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?

What are the functions of the endocannabinoid system?

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Overview of Molecular Physiology publications

Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Conference

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

LEAP is a peer-reviewed journal founded in 2021 by a team of junior and senior scholars of Leiden University as part of a Faculty-broad Master course. Each year the journal has a new editorial board and a new theme. Series editors Astrid van Weyenberg and Nanne Timmer guide this process and are assisted…

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).