Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

As LUC The Hague only has 200 places available for first year students, we select students based on multiple factors in order to assess best fit.

The Bachelor programme Psychology will admit a limited number of students (Numerus Fixus) for the academic year 2021-2022. A selection process will determine which applicants best fit our programme. Also, it is a good way for you to discover if Psychology in Leiden is the programme for you.

Promotor: Prof.dr. G.J. Kroes

Our selection and placement procedure starts with your application (i.e. prior to 15 January 2021) and ends with—hopefully—an invitation to you to enrol as an IRO student. This page tells you all you need to know about the steps to be taken in between.

Applying for the Leiden Leadership Programme is an option for students who are currently following or intending to follow a master’s programme at Leiden University or Delft University of Technology. The Leiden Leadership Programme starts once a year, in September; there is no intake in February.

Read all about how to become a YAL member on this page.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Vibrating carbon monoxide molecules adsorbed at the surface of a salt crystal stop moving after a few milliseconds. Scientists now discovered this is dominantly due to the emission of electromagnetic waves. The role of the chemical bond at the surface thereby appears to be less important than previously…

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Examining if large scale application of new energy pathways can be constrained by materials and emissions.

Juurlink

Sustainable energy from wind and solar is most readily available near the sea.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

How can the legal and socio-legal research skills of Indonesian jurists be increased in order to promote legal certainty and to strengthen the capacity of the judicial training in the country?

Both Europe and Latin America face challenges globally and at home. Conflicts over land and resources have been resurgent in recent years.

This dissertation focuses on the overt marking of φ features encoded on perfective active auxiliaries in a group of Southern Italian dialects.

The path to rational drug and dose selection

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

A Selection of the Poems of Sir Constantijn Huygens (1596-1687) was published in July 2015, edited and translated by Adriaan van der Weel and Peter Davidson.

An article that Holger Hoos, Professor of Machine Learning at the Leiden Institute of Advanced Computer Science (LIACS), wrote with his former Master student Jasper van Engelen has been selected by SpringerNature as one of six Research Highlights in Computer Science of 2020. After becoming an ACM Fellow…

Diacylglycerol lipase (DAGL)-α and -β are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). Selective and reversible inhibitors are required to study the function of DAGLs in neuronal cells in an acute and temporal fashion, but they are currently lacking.…

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

‘China has become an academic powerhouse, which is good reason for Leiden University to expand our partnerships with universities there.' A delegation headed by Rector Magnificus Carel Stolker visited China and South Korea, to renew and extend existing partnerships.

How can we make make accurate predictions for reactions of molecules on metal surfaces?

Prehistoric people may well have had an emotional bond with domesticated dogs much earlier than we thought. Leiden PhD candidate and vet Luc Janssens discovered that a dog found at the start of the last century in a grave dating back 14,000 years had been sick for a long time and had been cared for.…

A model method: A strategy that combines a knowledge-based in silico design approach and the development of novel activity-based probes (ABPs) for the detection of endogenous diacylglycerol lipase-α (DAGL-α) is presented. This approach resulted in the rapid identification of new DAGL-α inhibitors with…

FGGA students Amber Klompmaker (Master in Public Administration) and Imogen Liu (Research Master in Political Science and Public Administration) have been selected to participate in the Political Economy of Capitalism workshop of the Young Scholars Initiative of the Institute of New Economic Thinking…

EUniWell –the European University for Well-Being in which Leiden University and six other universities collaborate – is among the consortia selected for funding in the ‘European Universities Initiative’. The alliance will receive funding of 5 million euros from the European Commission.

How do you ensure that a drug has an effect on the right protein – and nothing else? Chemist Anthe Janssen explored various methods for determining the selectivity of potential medicines. He also looked at the substance BIA 10-2474, after a man died in a French clinical trial in 2016. PhD defence on…

The miniaturization of machines towards the micron and nanoscale requires the development of joint-like elements that enable and constrain motion. We developed a facile method to create colloidal joints, that is, anisotropic colloidal particles functionalized with surface mobile DNA linkers that control…

On 14 and 15 March, students can register as candidates for a place in the University Council (UR) or one of the faculty councils. But what do these participation bodies do? UR member Femke van der Meulen takes us through the agenda for the next meeting.

February 2019 will see the launch of the Young Academy Leiden (YAL). Founded by the Leiden members of De Jonge Akademie of the Royal Dutch Academy of Arts and Sciences, the YAL has been designed to support the university’s talented early career scholars.

In this project diverse aspects of the duchesses’ roles in the complex and dynamic relations between town and crown are studied on the basis of systematic research in the account books of four cities (Ghent, Bruges, Leuven and Mechelen) in the Burgundian Netherlands (ca. 1430-1503).

The OHBM Program Committee selected LUCL's Olga Kepinska to receive a Merit Abstract Award for the 2016 OHBM Annual Meeting in Geneva, Switzerland.

Leiden University has selected an architect for the realisation of its new beta-campus. As a team, Designers bureau Inbo in Rotterdam and JHK Architects have won the tender for phase 1, the new housing estate for the Faculty of Science.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Livia, aged 7, was in class four. She loved to chat and was good at reading aloud. At least, at home. At school she never read aloud and she hadn't spoken a single word. What was going on? Selective mutism was the subject of the inaugural lecture by Maretha de Jonge, Professor by Special Appointment…

Sylvie Ramakers of Leiden University College The Hague has been accepted to the prestigious Yenching Academy of Peking University in Beijing China, making her the third LUC alumnus in five years to break the ceiling of the notoriously competitive selection.

The European Commission has selected a consortium of major European launcher and satellite manufacturers, operators and service providers, as well as policy and legal research centres and institutes to study and provide guidelines and recommendations on Space Traffic Management (STM). The IIASL of Leiden…

Proparte is the Association of professors at Leiden University, their spouses and partners.

AstroEDU is one of the world's most inspiring education innovations, according to the experts at HundrED. It is a recognition for a place where educators can discover, review, change, and share astronomy- and space-related activities for primary and secondary education, and where they can have their…