Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in…

Conference

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

Science, Leiden Academic Centre for Drug Research (LACDR)

The competence oriented programme trains you to look and act with a cross-domain and innovative view; become an academic strategic partner who speaks the language of different domains, with focus on medicine, data science, behaviour and governance.

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

Physics and Engineering Approaches to Biomedicine and Pharmacology

This study focuses on increasing our understanding of the different pathways converts take during conversion to Islam.

Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?

How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

How is vegetative development regulated in plants and how does this affect a plant’s life history strategy?

Sub-Saharan Africa has seen a significant rise in terrorist acts and radicalized youth since the appearance of Boko Haram in 2009 and the fall of Libya in 2012. This book investigates the deeper layers of radicalization in Sub-Saharan Africa, which is situated in a larger global tendency.

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.

Through a range of case studies spanning the post-Cold War period in Iraq, Moldova and Serbia, this book studies asymmetric conflicts where warring sides exhibit vast power differentials.

What are the risks of nanoparticles?

In neonates and infants, body size, enzyme pathways, and expression and function of receptors and (target) proteins are still developing.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

Education development and enhancement, where do you start?

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

According to the Leiden University PhD Regulations associate professors (UHD's) can be granted 'ius promovendi' , the right to award a PhD. You can request the ius from the Doctorate Board via the Dean.

PhD Defence

PhD Defence

PhD Defence

PhD Defence

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

PhD Defence

PhD Defence

How do the pathways of Dutch converts to Islam involved in jihadist movements differ from those of Dutch converts who are not, in terms of their life prior to Islam, their conversion experience and the form of involvement with the Islamic community after conversion?

Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.

Promotor: H.V.J. Linnartz

TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

How to facilitate the translation of science into innovation

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Developing robust and comprehensive analytical methods to size and quantify subvisible particles in biopharmaceutical products.

Is there a sufficiently large market for drug screening and testing in Zebrafish larvae using membrane fusion?

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar