Prostate cancer (PCa) is one of the most prevalent cancer in males.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Can new variants of daptomycin and the polymyxins be found?

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Lecture

The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…

This dissertation reports on the pedagogical content knowledge (PCK) of science teachers during a professional development program. This research intended to help us understand why and how teachers make their classroom decisions as they teach science.

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

Conference, Work conference

Webinar | Cleveringa Dallaire critical conversation series

Identification and characterization of components of DNA repair pathways and their role in Agrobacterium T-DNA integration and repair of CRISPR/Cas induced DSBs.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

PhD Defence

PhD Defence

The mechanism of the electrochemical reduction of dioxygen by a mononuclear pyridylalkylamine copper complex was investigated (see picture). It was shown that in neutral aqueous solution dioxygen undergoes stepwise reduction, wherein hydrogen peroxide plays a key role. The rate constants determined…

Promotores: A.H. Meijer, H.P. Spaink

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Promotor: Prof.dr. R. Verpoorte, Co-promotores: Dr. Y.H.Choi, N.R. Mustafa

The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…

How are the epidermal lipid pathways involved in health and disease.

Which key factors contribute to effective land justice pathways for the protection of people’s land rights and prevention of conflict?

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Promotor: Prof.dr. J. Memelink

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

There is little evidence of the routes connecting Amerindian communities in the Caribbean prior to and just after 1492. Uncovering possible canoe routes between these communities can help to explain the structure, capabilities, and limitations of the physical links in their social and material networks.…

Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…

PhD Defence

Mechanisms fro drug resistance

How distance-dependent is graphene as biological sensor?

PhD Defence

PhD Defence

Science, Leiden Academic Centre for Drug Research (LACDR)

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

When and how does social anxiety develop? How can it go astray in some adolescents? How can we help troubled young people to attend school regularly and return to a normal developmental pathway?

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Our focus is to optimize the fungal cell wall to both increase chitin production and chitin extractability.

PhD Defence

PhD Defence