Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

The ambition to have flexible learning pathways is about creating possibilities to improve the content and form of students’ learning process, and to link learning to students’ needs. Students who have access to a flexible range of learning pathways can align their university career with their own personal…

... studies the developmental course and dynamics of cognition, self-regulation, and emotional competence, and the implications for educational and clinical practice.

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

How can you make your courses more flexible? On this page, you will discover various ways to design more flexible courses.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Examining if large scale application of new energy pathways can be constrained by materials and emissions.

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

Science, Leiden Institute of Chemistry (LIC)

Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Pathways of toxicity

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Dr. at Max Planck Institute for chemical Ecology, Jena - Germany

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

The article 'Co-productive agility and four collaborative pathways to sustainability transformations' is published in Global Environmental Change and accessible via OpenAccess. Professor Anthropology of Sustainability and Livelihood Marja Spierenburg of the Institute of Cultural Anthropology and Development…

Focus in skin research

Is it possible for sugar patterns on cells to activate the immune system to combat cancer?

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

High throughput microscopy

The Liverpool care pathway for the dying patient (LCP) is a multidisciplinary tool developed for the dying phase for use in palliative care settings. The literature reports divergent experiences with its application in a nursing home setting related to its implementation and staff competencies. The…

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Which microorganisms live near and inside plant roots? How do they contribute to plant health? Can microorganisms be employed in plant protection?

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.

This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.

Improvisers in experimental music do not record their music in a conventional score, but in ever-changing 'tactile pathways'. This is the proposition put forward by researcher Christopher Williams. PhD defence 13 December.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Promotor: B. van de Water

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

Promotores: J.C. van Houwelingen, S.A. van de Geer

ACPA alumni Falk Hübner and Joost Vanmaele aim to put up a few signposts in the expansive field of artistic research with an article recently published on FORUM+ .

What are the developmental pathways to social anxiety (disorder), the causal processes and maintaining factors? How do these factors interact in the development of social anxiety disorder? How can this knowledge be used to design and implement effective preventive intervention programs for youth?

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

Promotor: B. van de Water

We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.

On Friday October 30th 2015 the sixth annual Jan Reedijk Symposium will be held. The main lectures of the day will be

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Conference