64 search results for “biosynthesis” in the Public website
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Galactofuranose biosynthesis in the filamentous fungus Aspergillus niger
This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.
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Human epidermal lipid biosynthesis in health and disease
How are the epidermal lipid pathways involved in health and disease.
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Human skin equivalents: understanding the lipid biosynthesis in the skin
There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.
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and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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MYC transcription factors: masters in the regulation of jasmonate biosynthesis in Arabidopsis thaliana
Promotor: J.M. Memelink
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fungal endophytes in Vanilla planifolia on vanilla flavor compounds biosynthesis
Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.
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bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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patients and inflammation plays a role in the altered epidermal lipid biosynthesis
Source: Journal of Investigative Dermatology, Volume 135, pp. S59-S59 (2015)
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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken
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Robert Verpoorte
Science
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Young Hae Choi
Science
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Molecular characterization of copper-dependent enzymes involved in Streptomyces morphology
Promotor: G.P. van Wezel, Co-promotor: D. Claessen
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Metabolomic characteristics of Catharanthus roseus plants in time and space
Promotor: Prof.dr. R. Verpoorte, Co-promotores: Dr. Y.H.Choi, N.R. Mustafa
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea
Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.
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Total Synthesis of Alginate and Zwitterionic Sp1 Oligosaccharides
The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.
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Chemical Tools to Modulate Endocannabinoid Biosynthesis
PhD Defence
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Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons, J. Am.
Diacylglycerol lipase (DAGL)-α and -β are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). Selective and reversible inhibitors are required to study the function of DAGLs in neuronal cells in an acute and temporal fashion, but they are currently lacking.…
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Bernd Schneider
Dr. at Max Planck Institute for chemical Ecology, Jena - Germany
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Chemical Biology Lecture: Biosynthesis and Engineering of Cyclic Peptide Antibiotics
Lecture
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Endothelial Glycocalyx Hyaluronan Biosynthesis and Function in Microcirculation
PhD Defence
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
PhD Defence
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Activity-based protein profiling of diacylglycerol lipases
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Unilever Research Prize for master student Lukas Kiefer
Leiden Biology student Lukas Kiefer has won the Unilever Research Prize 2018 for his research into efficient production of a new antibiotic. Kiefer: ‘I want to make biological medicines available to people in need.'
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Unraveling the auxin mechanism in 2,4-D induced somatic embryogenesis in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa
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Robert Verpoorte
Emeritus professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands
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Key publications
Key publications of the Skin Barrier and Vaccination group.
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Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
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NO-ESKAPE New Strategies for Overcoming the ESKAPE Pathogens
Natural product inspired antibiotics to address resistance
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MYC transcription factors: masters in the regulation of jasmonate biosynthesis in Arabidopsis thaliana
PhD Defence
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bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
PhD Defence
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fungal endophytes in Vanilla planifolia on vanilla flavor compounds biosynthesis
PhD Defence
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François Mesnard
PhD at Université de Picardie Jules Verne, Amiens - France
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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ERC Synergy Grant to unlock sugar codes for health and a sustainable society
Hermen Overkleeft and his colleagues Gideon Davies (University of York) and Carme Rovira (University of Barcelona) will receive a 9.1 million euros Synergy Grant from the European Research Council. Together, they will form the Carbocentre Synergy team for research into enzymes that work on glycans:…
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Horizontal gene transfer and spreading of biosynthetic gene clusters and antimicrobial resistance
Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.
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Bioactive Molecules in Plant Sciences
Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.
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PhD Thesis: Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Recently, the PhD thesis of Lolu Danso Eweje appeared entitled ’Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin’.
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Research
The current projects of the Molecular Physiology group focus on kinases and proteins of the endocannabinoid system.
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PhD Theses
A full overview of MacBio PhD Theses.
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The role of auxin in somatic embryogenesis
What is the role of auxin in the initiation and process of somatic embryogenesis?
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Fungi add flavour to vanilla
Fungi living in vanilla plants play a role in the development of the taste and smell of vanilla, according to Shahnoo Khoyratty of the Institute of Biology Leiden. PhD defence on 27 October.
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Natural deep eutectic solvents: A new green solvent from nature
- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?
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Inaugural lecture Annemarie Meijer
On Monday 21 September Annemarie Meijer, Professor of Immunobiology, presented her inaugural lecture on immunobiology and infectious disease.
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Hui Deng wins ICRS Award at an international meeting in Poland
Hui Deng (MSc.), a PhD-student in the department of Molecular Physiology, has received an award for the best oral presentation during the 26th International Cannabinoid Research Society (ICRS) conference with more than 300 participants in Bukovina, Poland. Hui Deng presented her work on “Rapid and…
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“Principles of Plant-Microbe Interactions”
Emeritus Professor Ben Lugtenberg edited a book on “Principles of Plant-Microbe Interactions” together with Paul Hooykaas, Eddy van der Meijden and Jos Raaijmakers, all from the IBL.