How distance-dependent is graphene as biological sensor?

Promotor: T. H. Oosterkamp

Schneider

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Science, Leiden Academic Centre for Drug Research (LACDR)

We study the physics of a broad range of biological and soft materials

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Can we build a biosensor to detect neuroblastoma markers in urine using the chemotaxis system in E. coli?

Science, Leiden Academic Centre for Drug Research (LACDR)

Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

The Physics and Biological and Soft Matter master's specialisation is one of the two programmes that Leiden University offers in experimental physics. This programme mainly focuses on Biological Physics and Soft Matters Physics.

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?

Leiden and Jülich researchers discovered an elegant and simple approach to improve the sensitivity of graphene biosensors. These so-called ‘next generation graphene electronic biochemical sensor devices’ are able to detect very low amounts of HIV DNA thanks to their very low electronic noise.

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Are there acoustic cues for settlement stage larvae in deep-sea soundscapes around hydrothermal vents?

How do nanoparticles bioaccumulate and biodistribute in organisms?

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.

Promotores: H. Schiessel, G.T. Barkema

Free playtime and physical play are of great importance to children's social development. That is the main conclusion of innovative research by developmental psychologists and computer scientists from Leiden University.

This year's Nobel Prize for Medicine goes to the three American researchers who have unravelled the mechanism behind the biological clock. Joke Meijer, Professor of Neurophysiology and an expert in the field of the sleep-wake rhythm, explained in Dutch newspapers Trouw and NRC why this discovery is…

What is vegetation structure and composition in SFM primary forest, secondary logged over forest (logging FSC certified and logging non certified) in comparison to primary forest? What is avian guild diversity in SFM primary forest, secondary logged over forest (logging FSC certified and logging non…

Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

Description of The Regional Network on the Synergy between the Convention on Biological Diversity and the UN Convention to Combat Desertification.

Promotor: E. Bouwman Co-Promotor: S. Bonnet

Researchers at LUMC are trying to decipher the biological clock. This knowledge can help deal with luxury problems, such as jetlag, but can also counter diseases. Molecular neurobiologist Erno Vreugdenhil explains.

The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…

As fruit and vegetables ripen, ethylene gas is released. Ethylene also influences the speed at which they ripen. Chemist Tom van Dijkman studied how small and inexpensive sensors can be made that measure ethylene concentrations during transportation. PhD defence 12 May 2016.

Can we find new chemical and biological sensing routes on the edge and surface of graphene to improve the potential of graphene to act as a sensor?

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Plants use sunlight to perform photosynthesis, but with too much light they have to dim their activity and protect their cells against photo damage. The protein PsbS acts as a light-stress sensor and plays a key role in this process. Article in Nature’s Scientific Reports.

On Friday the 6th of December, the annual symposium of the IBL was organized at the Buruma theatre (LUMC), Leiden. This year’s theme was “Biological Networks from Molecules to Society”.

Research at the SBC group is comprised of the following research themes:

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

In August-September 2016 three CML students are doing an exciting field work in sub-arctic tundra in Sweden in collaboration with Ümea University.