Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

The substance galanthamine from flower bulbs can fight symptoms of Alzheimer's disease. Nadeem Akram investigated how daffodils can optimally produce this natural remedy. PhD defence on 24 June.

The European Research Council (ERC) has awarded Nathaniel Martin a Proof of Concept (PoC) grant. With it, his group aims to make a dangerous but potent antibiotic less toxic. He receives €150.000.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

After 41 years, Meindert Danhof, Professor of Pharmacology, is leaving the Leiden Academic Centre for Drug Research on 31 March. A symposium in his honour, prior to his farewell lecture, will show what has been achieved in this period. Danhof takes a look back on his career.

Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Mechanical interactions between cells and their environment play an important role in many biological processes.

Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.

Can we link multiple components from herbal extracts with their biological activities?

This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.

What chemicals do plants have available, and what happens if they use them when faced with bacteria or fungi? That is what PhD candidate Luis Salomé Abarca is keen to learn. He studies plants’ survival and their use of chemical components in communication and defence. Salomé Abarca works at the Natural…

Promotor: Prof.dr. J. Zaanen, A. Parnachev

Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.

Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

What are the functions of autophagy in the filamentous fungus Aspergillus niger?

Our focus is to optimize the fungal cell wall to both increase chitin production and chitin extractability.

Dave R. Stikkolorum, Michel R.V. Chaudron, Oswald de Bruin won the Best Paper Award of the Model Gamification Contest at the ACM/IEEE Models 2012 Conference for their paper: The Art Of Software Design, a Video Game for Learning Design Principles.

Professor at the School of pharmaceutical sciences, University of Geneva - Switzerland

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Cosmologists have many possible models for the Universe, of which only one can be true. A new flowchart will eliminate some of them when two specific Universe features are accurately measured. Publication in Physical Review D on 7 November.

We like to welcome you kindly to the Dutch Extract Library.

In Microbial Sciences, we perform multidisciplinary research to understand the structure and function of microbes at all levels of biological organization, from small molecules and cellular structures at atomic resolution to multicellular communities.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

The financial system needs complexity theory to predict economic crises like the 2008 meltdown. An international team of scientists, including Leiden physicist Diego Garlaschelli, state this in a paper published in Science on February 19th.

Current means of fighting bacteria are no longer as good as they used to be because of antibiotic resistance. These days, people are dying from bacterial infections that could have been cured fifty years ago.

Professor Carlo Beenakker has been awarded a FOM Projectruimte subsidy to build a theoretical model of a majorana gun, a very promising instrument for quantum computers.

A modeling approach with applications to the Bau de l'Aubesier (Southeastern France)

Using artificial intelligence to find new antibiotics. With that, researchers from Leiden University are nominated by magazine KIJK for the Best Tech-idea of 2021. From September 14 onwards people can vote to crown one of the nominees as the winner.

The opportunity to explore a new, exciting research topic. That is how Lennart Schada von Borzyskowski describes his successful application for the NWO XS grant. It comprises 50,000 euros, which the researcher from the Institute of Biology Leiden (IBL) will spend on investigating a more sustainable…

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

The SNP genotyping line offers flexible genotyping for small and large projects at affordable price and high quality. The use as SNPs as molecular markers is very versatile and can be used for a wide variety of scientific questions ranging from paternity analysis, conservatuion genetis towards QTL…

The main methodological aspects of the use of stepwise LCA estimators under different circumstances.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Identifying novel antibiotic compounds to tackle antibiotic-resistant bacteria. Researchers from Leiden University and VU Amsterdam will unite through a project now funded by NWO’s Open Technology Programme (OTP), which awarded the collaboration nearly one million euros.

Experts from several disciplines have raised concerns about the use of seemingly precise models to guide policies in matters as complex as the current Covid-19 pandemic. 22 scholars wrote down five principles on how to responsibly use scientific models. This comment was published in Nature on 24 June…