This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

The Leiden Bio Science Park (BSP) will become a real campus in the coming years, with more houses, and attractive places where scientists, students and entrepreneurs can meet to discuss their plans.

PURPOSE: To monitor the biodistribution of IgG1 aggregates upon subcutaneous (SC) and intravenous (IV) administration in mice and measure their propensity to stimulate an early immune response.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

The aim of this project is to study what makes an act or form of violence a specifically political reality.

In Shimmering Images, Eliza Steinbock traces how cinema offers alternative ways to understand gender transitions through a specific aesthetics of change.

How do documentary moving images and fictional narratives involve and evolve each other?

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

Promotor: C.U. Keller, Co-Promotor: F. Snik

The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market.

This project aims to study the Aesopian fable from 1500 to the present day in its complex relationship between text, illustration and education, adopting a broad, transnational perspective.

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

In the latest newsletter of the Leiden Bio Science Park you can find information about participating in a new European Research Project, the 25th Lab Career Event and the 'Kennisfestival 2009'!

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

The most famous monument of the Dutch Golden Age is undoubtedly the Amsterdam Town Hall by architect Jacob van Campen inaugurated in 1655.

PhD defence

PhD defence

PhD defence

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

PhD defence

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Ida Haisma has been appointed Director of the Leiden Bio Science Park. She will lead the transformation of the Leiden Bio Science Park from science park to innovation district. To this end, she will set up a new park organisation and act as the spokesperson for the park.

The Leiden Bio Science Park is nominated for Best Business Park in the Netherlands. The competition is set up by 'Bedrijventerrein Magazine'.

A technique originally developed for satellite imaging can now be used to recover pictographic texts from underneath the surface of a five hundred year old Mexican manuscript.

Many students cycle past the companies of the Bio Science Park every day, but what actually happens behind those doors? And is there a future there for students after their graduation? The Bio Science Park Excursion answers these questions.

Joost Batenburg is a mathematician and computer scientist who works to build bridges to other disciplines. He hopes to bring intelligent software to fields where it can make a difference. Conversely, he also seeks connections to the disciplines that are needed to make AI a success.

The Microscopy Unit houses, maintains and coordinates most of the microscopy equipment of the IBL. The available equipment ranges from conventional light and fluorescence microscopes, to confocal laser scanning and electron microscopes. In addition, infrastructure is available for histology, including…

Which immune mechanisms are involved in host defense against Staphylococcal infection?

American pharmaceutical company Bristol Myers Squibb will be building a new (CAR-T) cell therapy facility in the Oegstgeest part of the Leiden Bio Science Park. The company will manufacture and develop CAR T-cell therapy for patients with blood cancer (leukaemia), for example.

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.

The Animated Image addresses the entire range of contexts in which images were described by Roman authors as being animated, as well as the accounts that Roman writers produced to explain the animation of inanimate matter.

Imaging and Imagining Palestine is the first comprehensive study of photography during the British Mandate period (1918–1948).

Analysis of drug adversity

In Film and Video Intermediality, Janna Houwen innovatively rewrites the concept of medium specificity in order to answer the questions “what is meant by video?” and “what is meant by film?”

For Harry Flore, chair of the LBSP business asociation and CEO at Hal Allergy, the Leiden Bio Science Park (LBSP) has no secrets. But he can well imagine the park is a black box for some staff and students at the university: 'I welcome collaboration on all fronts.'

The transition period in which men become fathers might provide an important window of opportunity for parenting interventions that may produce long-term positive effects on paternal care and, consequently, child development. Existing prenatal programs traditionally focus on maternal and infant health…

These are the staff members of the Leiden - Latin America and the Caribbean Centre

Pharma company Janssen has begun construction on a new office and lab building at the Leiden Bio Science Park. The first pile of the 13,500 square metre building has been driven into the ground.

International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Fish climbing trees, storks taking care of their parents… Premodern textual and visual culture presents us with a fabulous bestiary that reveals ingenious and rich reflections on the animal kingdom.

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

Compact Cinematics challenges the dominant understanding of cinema to focus on the various compact, short, miniature, pocket-sized forms of cinematics that have existed from even before its standardization in theatrical form, and in recent years have multiplied and proliferated, taking up an increasingly…

How can the importance of the image in late medieval spirituality be understood in the context of the love mysticism inspired by the imagery of the Song of Songs?