Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

Young children exhibit more aggressive behaviour if their nervous system fails to respond adequately to stress situations and if they are exposed to risk factors such as smoking or psychological problems experienced by the mother during the pregnancy. This is the conclusion of PhD candidate Jill Suurland.…

Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior

What are the functions of the endocannabinoid system?

The collaboration between Leiden University (Medical Center) and the Autonomous University of Barcelona forms one of the most powerful international alliances for the creation and transmission of knowledge in the field of transfusion medicine.

Squatters and autonomous movements have been in the forefront of radical politics in Europe for nearly a half-century—from struggles against urban renewal and gentrification, to large-scale peace and environmental campaigns, to spearheading the antiausterity protests sweeping the continent.

Can excessive worrying be reduced via stimulation of the vagus nerve?

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

The Forensic Family and Youth Care Studies research group conducts innovative high-quality research aiming to gain knowledge about deviant developmental trajectories of vulnerable children, adolescents, and families, about how to prevent problematic development and how to intervene when necessary.

When abusive mothers hear crying babies, their autonomous nervous system does not react strongly enough. This is the conclusion reached by Sophie Reijman, PhD candidate in Child and Family Studies, in her research. This finding may provide leads for reducing child abuse. Defence on 16 December.

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: J.N. Kok, Co-promotor: H.J. Hoogeboom

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

The Systems Pharmacology group is headed by Prof. Piet Hein van der Graaf. Systems Pharmacology is the quantitative analysis of the dynamic interactions between drugs and a biological system to understand the behaviour of the system as a whole, as opposed to the behaviour of its individual constituents;…

In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Here are some systems and infrastructures that are useful to students.

Russia is planning to protect its own internet against attacks from the Western enemy. President Putin recently signed a law for autonomous internet as a kick off. Critics are worried that the law will mainly be used to oppress the opposition within Russia itself. Dennis Broeders, Associate Professor…

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Every year, Leiden University welcomes some 27,000 students from 115 different countries. In educating these students, we are committed to ensuring that the quality of our tuition meets or exceeds the highest-possible standards.

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

Xinrong Ma defended her thesis on 13 February 2018

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

The correctness of computational systems is of great importance to our society, since it becomes ever more reliant on the benefits of computing.

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

The research of our group is centered around dynamical systems, functional analysis and their interplay.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Students in Leiden are entitled to good teaching and good supervision. For their part, there are some conditions they have to meet to ensure that they complete their studies within the time allotted.

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.

The two-years master’s specialisation System Biomedicine and Pharmacology at Leiden university focuses on predicting drug response with computational modelling, developing individualised therapies, and developing innovative analytical tools for personalised health strategies.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

Interaction between Legal Systems acknowledges that law-making and law enforcement are increasingly taking place on various levels: in a global context, in EU context, on a national level and in a private law framework. These levels influence each other, sometimes directly, on the basis of a hierarchical…

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

How do balanced lethal systems originate and persist in nature?

The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

This book explores the boundaries of the category of gender and their theoretical significance within the framework of Canonical Typology.